Tetracycline

Generic Name
Tetracycline
Brand Names
Pylera, Sumycin
Drug Type
Small Molecule
Chemical Formula
C22H24N2O8
CAS Number
60-54-8
Unique Ingredient Identifier
F8VB5M810T
Background

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal sub...

Indication

Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical orga...

Associated Conditions
Acinetobacter Infections, Actinomycosis, Anthrax, Bacterial Infections, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydial Infections, Cholera (Disorder), Clostridium Infections, Conjunctivitis, Inclusion, Cystitis, Endometritis, Entamoebic histolytica infection, Escherichia infections, Granuloma Inguinale, Helicobacter Pylori Infection, Infection, Infection, Bacteroides, Klebsiella Infections, Listeria infection, Lower respiratory tract infection bacterial, Lymphogranuloma Venereum, Necrotizing ulcerative gingivostomatitis, Neisseria Gonorrhoeae Infection, Nephritis, Ornithosis, Plague, Prostatitis, Psittacosis, Q Fever, Relapsing Fever, Rickettsialpox, Rocky Mountain Spotted Fever, Rosacea, Severe Acne, Shigella Infection, Skin Infections caused by Staphylococcus Aureus, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Trachoma, Tularemia, Typhus, Upper respiratory tract infection bacterial, Urinary Tract Infection, Yaws, Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection
Associated Therapies
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Helicobacter Rescue Therapy With High-dose Esomeprazole and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy

First Posted Date
2020-12-22
Last Posted Date
2023-01-31
Lead Sponsor
Xijing Hospital of Digestive Diseases
Target Recruit Count
658
Registration Number
NCT04678492
Locations
🇨🇳

Xijing Hosipital of Digestive Disease, Xi'an, Shaanxi, China

Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

First Posted Date
2019-08-26
Last Posted Date
2019-08-28
Lead Sponsor
HK inno.N Corporation
Target Recruit Count
32
Registration Number
NCT04066257
Locations
🇰🇷

Chonbuk National University Hospital, Jeonju, Korea, Republic of

Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy

First Posted Date
2018-10-17
Last Posted Date
2019-12-10
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
112
Registration Number
NCT03708848
Locations
🇨🇳

Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Effects of Antimicrobials on the Altered Skin Flora in Arsenical Keratosis

First Posted Date
2018-08-15
Last Posted Date
2018-08-17
Lead Sponsor
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Target Recruit Count
30
Registration Number
NCT03632733
Locations
🇧🇩

Eruain Community Clinic, Laksham, Bangladesh

Genotypic Resistance Guided Therapy for Refractory H. Pylori Infection

First Posted Date
2018-06-13
Last Posted Date
2018-06-13
Lead Sponsor
National Taiwan University Hospital
Target Recruit Count
320
Registration Number
NCT03555526
Locations
🇨🇳

Jyh-Ming Liou, Taipei, Taiwan, Taiwan-, Taiwan

Sanitation, Water, and Instruction in Face-washing for Trachoma I/II

First Posted Date
2016-04-28
Last Posted Date
2023-08-21
Lead Sponsor
University of California, San Francisco
Target Recruit Count
340000
Registration Number
NCT02754583
Locations
🇪🇹

The Carter Center Ethiopia, Addis Ababa, Ethiopia

High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection

First Posted Date
2014-06-26
Last Posted Date
2016-03-01
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
312
Registration Number
NCT02175927
Locations
🇨🇳

Shanghai Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, Shanghai, China

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