Tetracycline

Generic Name: Tetracycline

Brand Names: Pylera, Sumycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 60-54-8

Unique Ingredient Identifier: F8VB5M810T

Background: Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal sub...

Indication: Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical orga...

Associated Conditions: Acinetobacter Infections, Actinomycosis, Anthrax, Bacterial Infections, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydial Infections, Cholera (Disorder), Clostridium Infections, Conjunctivitis, Inclusion, Cystitis, Endometritis, Entamoebic histolytica infection, Escherichia infections, Granuloma Inguinale, Helicobacter Pylori Infection, Infection, Infection, Bacteroides, Klebsiella Infections, Listeria infection, Lower respiratory tract infection bacterial, Lymphogranuloma Venereum, Necrotizing ulcerative gingivostomatitis, Neisseria Gonorrhoeae Infection, Nephritis, Ornithosis, Plague, Prostatitis, Psittacosis, Q Fever, Relapsing Fever, Rickettsialpox, Rocky Mountain Spotted Fever, Rosacea, Severe Acne, Shigella Infection, Skin Infections caused by Staphylococcus Aureus, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Trachoma, Tularemia, Typhus, Upper respiratory tract infection bacterial, Urinary Tract Infection, Yaws, Grade 1, grade 2, grade 3, grade 4 Urinary Tract Infection

Associated Therapies: -

Clinical Trials

Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea

Not Applicable

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Pantoprazole
Drug: Amoxicillin
Drug: Clarithromycin
Drug: Tetracycline
Drug: Bismuth
Drug: Metronidazole

First Posted Date: 2014-06-10

Last Posted Date: 2019-05-13

Lead Sponsor: Seoul National University Bundang Hospital

Target Recruit Count: 390

Registration Number: NCT02159976

Locations: 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib)

Phase 2

Completed

Conditions: Skin Rash
Lung Cancer

Interventions: Drug: Tetracycline

First Posted Date: 2013-06-19

Last Posted Date: 2023-05-23

Lead Sponsor: Instituto Nacional de Cancerologia de Mexico

Target Recruit Count: 107

Registration Number: NCT01880515

Locations: 🇲🇽
Instituto Nacional de Cancerología, Mexico City, Mexico

Long-term Follow up Helicobacter Pylori Reinfection Rate After Second-Line Treatment: Bismuth-Containing Quadruple Therapy Versus Moxifloxacin-Based Triple Therapy

Phase 4

Completed

Conditions: Helicobacter Infections

Interventions: Drug: esomeprazole
Drug: moxifloxacin
Drug: tripotassium dicitrate bismuthate
Drug: amoxicillin
Drug: metronidazole
Drug: tetracycline

First Posted Date: 2013-02-15

Last Posted Date: 2013-02-15

Lead Sponsor: Seoul National University Bundang Hospital

Target Recruit Count: 648

Registration Number: NCT01792700

Locations: 🇰🇷
Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea, Republic of

Intralesional Tetracycline Injection in the Treatment of Chalazia

Early Phase 1

Withdrawn

Conditions: Chalazia
Chalazion

Interventions: Drug: Tetracycline

First Posted Date: 2013-01-08

Last Posted Date: 2017-01-12

Lead Sponsor: The Cleveland Clinic

Registration Number: NCT01763437

Locations: 🇺🇸
Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, United States

Effects of Teriparatide or Denosumab on Bone in Postmenopausal Women With Osteoporosis

Phase 4

Completed

Conditions: Osteoporosis

Interventions: Drug: Teriparatide
Drug: Denosumab
Drug: Demeclocycline
Drug: Tetracycline
Drug: Calcium Supplement
Drug: Vitamin D

First Posted Date: 2012-12-20

Last Posted Date: 2015-10-08

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 69

Registration Number: NCT01753856

Locations: 🇨🇦
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Sainte-Foy, Quebec, Canada