Lorazepam
- Generic Name
- Lorazepam
- Brand Names
- Ativan, Loreev
- Drug Type
- Small Molecule
- Chemical Formula
- C15H10Cl2N2O2
- CAS Number
- 846-49-1
- Unique Ingredient Identifier
- O26FZP769L
- Background
Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.
- Indication
Lorazepam is FDA-approved for the short-term relief of anxiety symptoms related to anxiety disorders and anxiety associated with depressive symptoms such as anxiety-associated insomnia. It is as well used as an anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia and for the treatment of status epilepticus.
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- Associated Conditions
- Agitation, Alcohol Withdrawal Delirium, Alcohol Withdrawal Syndrome, Anxiety, Anxiety Disorders, Chemotherapy-Induced Nausea and Vomiting, Delirium, Insomnia, Muscle Spasms, Panic Disorder, Psychogenic Catatonia, Status Epilepticus
- Associated Therapies
- Anesthetic premedication therapy
A Sedation/Cognition/Electroencephalogram (EEG) Study Using AZD7325 and Comparator.
- First Posted Date
- 2008-07-22
- Last Posted Date
- 2010-12-10
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 16
- Registration Number
- NCT00720421
- Locations
- 🇳🇱
Centre for Human Drug Research, Leiden, Netherlands
Clinical Study Assessing a New Scale to Measure Onset of Action in Generalized Anxiety Disorder
- Conditions
- Interventions
- First Posted Date
- 2008-07-15
- Last Posted Date
- 2008-10-03
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 169
- Registration Number
- NCT00715039
- Locations
- 🇺🇸
Pfizer Investigational Site, Cincinnati, Ohio, United States
Exploring the Effects of Diazepam and Lorazepam
- Conditions
- Interventions
- First Posted Date
- 2008-06-12
- Last Posted Date
- 2009-09-17
- Lead Sponsor
- University Hospital, Strasbourg, France
- Target Recruit Count
- 22
- Registration Number
- NCT00696033
- Locations
- 🇫🇷
Centre d'investigation clinique, hôpital civil, Strasbourg, France
🇫🇷Clinique psychiatrique, hôpital civil, Strasbourg, France
Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients
- Conditions
- Interventions
- First Posted Date
- 2008-03-24
- Last Posted Date
- 2018-04-03
- Lead Sponsor
- Lehigh Valley Hospital
- Target Recruit Count
- 26
- Registration Number
- NCT00641797
- Locations
- 🇺🇸
Lehigh Valley Hospital, Allentown, Pennsylvania, United States
Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder
- Conditions
- Interventions
- First Posted Date
- 2008-02-27
- Last Posted Date
- 2021-01-28
- Target Recruit Count
- 615
- Registration Number
- NCT00624780
- Locations
- 🇹🇷
Pfizer Investigational Site, Kocaeli, Turkey
Treating Alcohol Withdrawal With Oral Baclofen
- Conditions
- Interventions
- First Posted Date
- 2008-01-18
- Last Posted Date
- 2011-07-27
- Lead Sponsor
- Essentia Health
- Target Recruit Count
- 79
- Registration Number
- NCT00597701
- Locations
- 🇺🇸
Essentia Health, Duluth, Minnesota, United States
The Impact of Lorazepam on Cognition in APOE e4 Carriers
- First Posted Date
- 2008-01-04
- Last Posted Date
- 2008-01-04
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 36
- Registration Number
- NCT00586430
- Locations
- 🇺🇸
Mayo Clinic, Scottsdale, Arizona, United States
A Comparison of Lorazepam and Diazepam in the Treatment of Alcohol Withdrawal
- First Posted Date
- 2007-08-31
- Last Posted Date
- 2007-08-31
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 55
- Registration Number
- NCT00523185
- Locations
- 🇺🇸
Palo Alto Veterans Affairs Hospital System, Palo Alto, California, United States
🇺🇸Stanford Hospital and Clinics, Stanford, California, United States
A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room
- Conditions
- Interventions
- First Posted Date
- 2007-04-06
- Last Posted Date
- 2019-07-26
- Lead Sponsor
- University of Southern California
- Target Recruit Count
- 72
- Registration Number
- NCT00457366
- Locations
- 🇺🇸
Los Angeles County Hospital, Los Angeles, California, United States
Effects of Pentazocine Versus Lorazepam on Manic Symptoms
- Conditions
- Interventions
- First Posted Date
- 2007-02-05
- Last Posted Date
- 2019-03-06
- Lead Sponsor
- Mclean Hospital
- Target Recruit Count
- 19
- Registration Number
- NCT00431184
- Locations
- 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.