Sevoflurane

Generic Name: Sevoflurane

Brand Names: Sevorane, Sojourn, Ultane

Drug Type: Small Molecule

Chemical Formula: C_₄H_₃F_₇O

CAS Number: 28523-86-6

Unique Ingredient Identifier: 38LVP0K73A

Background: Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication: Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery

Phase 3

Completed

Conditions: Baxter Anaesthesia Brand of Desflurane
Cystoscopes
Sevoflurane

Interventions: Drug: Desflurane
Drug: Sevoflurane

First Posted Date: 2010-10-13

Last Posted Date: 2021-11-16

Lead Sponsor: Ohio State University

Target Recruit Count: 75

Registration Number: NCT01219881

Locations: 🇺🇸
The Ohio State University Medical Center, Columbus, Ohio, United States

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

Completed

Conditions: Blindness

Interventions: Drug: Sevoflurane
Drug: propofol

First Posted Date: 2010-10-13

Last Posted Date: 2015-04-24

Lead Sponsor: Rutgers, The State University of New Jersey

Target Recruit Count: 35

Registration Number: NCT01219569

Locations: 🇺🇸
University Hospital, Newark, New Jersey, United States

A Pilot Study to Investigate Plasma Bupivacaine Concentrations in Children Receiving Total Intravenous Anaesthesia and Caudal Analgesia

Phase 1

Completed

Conditions: Anesthesia

Interventions: Drug: sevoflurane
Drug: propofol

First Posted Date: 2010-10-07

Last Posted Date: 2017-06-26

Lead Sponsor: University of British Columbia

Target Recruit Count: 30

Registration Number: NCT01216007

Locations: 🇨🇦
BC Children's Hospital, Department of Anesthesia, Vancouver, British Columbia, Canada

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

Phase 4

Completed

Conditions: Airway Reflexes, Protective
Recovery After Neuromuscular Block
Anesthetic Recovery

Interventions: Drug: Sevoflurane
Drug: Desflurane
Drug: Rocuronium
Drug: Neostigmine
Drug: Glycopyrrolate

First Posted Date: 2010-09-10

Last Posted Date: 2014-05-16

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 107

Registration Number: NCT01199237

Locations: 🇺🇸
UCSF Moffitt-Long Hospital, San Francisco, California, United States
🇺🇸
UCSF Helen Diller Cancer Center, San Francisco, California, United States

Hip Fracture Surgery in Elderly Patients

Phase 2

Completed

Conditions: Delirium

Interventions: Drug: Xenon
Drug: Sevoflurane

First Posted Date: 2010-09-10

Last Posted Date: 2015-07-27

Lead Sponsor: Air Liquide Santé International

Target Recruit Count: 256

Registration Number: NCT01199276

Locations: 🇧🇪
UZ Leuven, Leuven, Belgium
🇫🇷
Centre Hospitalier Universitaire de Grenoble, La Tronche, France
🇫🇷
Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France

and more 10 locations

Long-term Outcome of General Anesthesia on Dysgnosia

Phase 4

Conditions: Delirium,
Dementia,
Amnestic,
Cognitive Disorders

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2010-08-19

Last Posted Date: 2014-01-14

Lead Sponsor: Nanjing Medical University

Target Recruit Count: 10000

Registration Number: NCT01184638

Locations: 🇨🇳
Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, China

Ventilatory Effect on Speed of Anesthesia Under Various Inhaled Anesthetics

Not Applicable

Completed

Conditions: Pharmacokinetics of Inhaled Anesthetics

Interventions: Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane

First Posted Date: 2010-07-29

Last Posted Date: 2012-08-13

Lead Sponsor: DongGuk University

Target Recruit Count: 36

Registration Number: NCT01171833

Cardiovascular Safety of Xenon in General Anaesthesia, in Patient With Cardiovascular Risk in Non Cardiac Surgery

Phase 3

Completed

Conditions: Elevated Cardiac Risk
Coronary Arteries Disease Risk

Interventions: Drug: Xenon
Drug: Sevoflurane

First Posted Date: 2010-05-11

Last Posted Date: 2014-06-17

Lead Sponsor: Air Liquide Santé International

Target Recruit Count: 600

Registration Number: NCT01120405

Locations: 🇫🇷
Centre Hospitalier Universitaire de Caen - Pôle Anesthésie-Réanimation-SAMU, Avenue de la Côte de Nacre, Caen, Calvados, France
🇫🇷
Nouvel Hopital Civil, Strasbourg, Bas Rhin, France
🇫🇷
CHU Nord, Marseille, Bouches du Rhône, France

and more 10 locations