Sevoflurane
- Generic Name
- Sevoflurane
- Brand Names
- Sevorane, Sojourn, Ultane
- Drug Type
- Small Molecule
- Chemical Formula
- C4H3F7O
- CAS Number
- 28523-86-6
- Unique Ingredient Identifier
- 38LVP0K73A
- Background
Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.
- Indication
Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
- Associated Conditions
- -
- Associated Therapies
- General Anesthesia, Induction and Maintenance of General Anesthesia
Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram
- Conditions
- Middle Aged PatientsSevofluraneGeneral Anesthesia
- Interventions
- First Posted Date
- 2012-08-10
- Last Posted Date
- 2012-08-14
- Lead Sponsor
- Huazhong University of Science and Technology
- Target Recruit Count
- 31
- Registration Number
- NCT01662622
- Locations
- 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Laryngeal Injuries After Removal of the Tracheal Tube: A Comparison Between Sevoflurane and Propofol
- Conditions
- Vocal Cord; Injury, Superficial
- Interventions
- First Posted Date
- 2012-06-12
- Last Posted Date
- 2012-07-03
- Lead Sponsor
- University of Rostock
- Target Recruit Count
- 65
- Registration Number
- NCT01616966
- Locations
- 🇩🇪
University of Rostock, Rostock, Mecklenburg/Vorpommern, Germany
Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)
- Conditions
- Myocardial Reperfusion Injury
- Interventions
- First Posted Date
- 2012-05-18
- Last Posted Date
- 2014-01-29
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 30
- Registration Number
- NCT01601795
- Locations
- 🇨🇭
University Hospital of Basel, Basel, Switzerland
Laryngeal Injuries After Anesthesia Induction With Sevoflurane and After Anesthesia Induction With Rocuronium
- First Posted Date
- 2012-05-03
- Last Posted Date
- 2013-02-15
- Lead Sponsor
- University of Rostock
- Target Recruit Count
- 60
- Registration Number
- NCT01591031
- Locations
- 🇩🇪
University of Rostock, Rostock, Mecklenburg/Vorpommern, Germany
The Effect of Different Sevoflurane Concentrations on Intraocular Pressure in Patients Undergoing Ocular Surgery Under General Anesthesia
- Conditions
- IOP Changes Due to Anesthesia (Healthy Patients)
- Interventions
- First Posted Date
- 2012-04-11
- Last Posted Date
- 2012-04-11
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT01575626
- Locations
- 🇮🇱
Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects
- Conditions
- Airway Complication of AnaesthesiaHealthy
- Interventions
- First Posted Date
- 2012-03-20
- Last Posted Date
- 2016-09-13
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 18
- Registration Number
- NCT01557920
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia
- First Posted Date
- 2012-03-09
- Last Posted Date
- 2015-01-27
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 236
- Registration Number
- NCT01549990
- Locations
- 🇰🇷
Severance Hospital, Seoul, Korea, Republic of
Comparison of the Effects of Sevoflurane and Midazolam Used for the Maintenance of Anaesthesia on the Levels of Postoperative Cardiac Troponin I in Pediatric Cardiac Surgery
- Conditions
- Myocardial InjuryAnaesthetic Preconditioning
- Interventions
- First Posted Date
- 2012-03-08
- Last Posted Date
- 2012-03-08
- Lead Sponsor
- Baskent University
- Target Recruit Count
- 50
- Registration Number
- NCT01548859
- Locations
- 🇹🇷
Baskent University, Faculty of Medicine, Ankara, Çankaya, Turkey
Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
- First Posted Date
- 2011-12-07
- Last Posted Date
- 2013-07-23
- Lead Sponsor
- The Catholic University of Korea
- Target Recruit Count
- 70
- Registration Number
- NCT01486953
- Locations
- 🇰🇷
Seoul St. Mary's Hospital, Seoul, Korea, Republic of
Anesthesia and Lymphocytes Apoptosis
- Conditions
- Anesthesia
- Interventions
- First Posted Date
- 2011-10-28
- Last Posted Date
- 2015-05-22
- Lead Sponsor
- Ruijin Hospital
- Target Recruit Count
- 105
- Registration Number
- NCT01461551
- Locations
- 🇨🇳
Ruijin Hospital, Shanghai, Shanghai, China
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.