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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
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Not Applicable
Terminated
Conditions
Sedation
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Interventions
Drug: Midazolam
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Remifentanil
Drug: Propofol
First Posted Date
2018-01-23
Last Posted Date
2019-06-12
Lead Sponsor
Changhai Hospital
Target Recruit Count
28
Registration Number
NCT03406533
Locations
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Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China

Bispectral Index(BIS) on Depth of Sedation With Dexmedetomidine, Propofol and Midazolam During Spinal Anesthesia

Not Applicable
Conditions
Anesthesia, Spinal
Sedation
Interventions
Drug: Propofol
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2018-01-16
Last Posted Date
2018-01-16
Lead Sponsor
Hallym University Medical Center
Target Recruit Count
45
Registration Number
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Locations
🇰🇷

Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Korea, Republic of

BIS of Sedation Depth During Flexible Bronchoscopy.

Not Applicable
Conditions
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Interventions
Drug: Fentanyl
Drug: Midazolam
Drug: Propofol
Device: Bispectral Index monitoring
First Posted Date
2018-01-10
Last Posted Date
2018-01-10
Lead Sponsor
Nanjing First Hospital, Nanjing Medical University
Target Recruit Count
500
Registration Number
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Propofol Versus Midazolam for Lower Gastrointestinal Endoscopy

Phase 3
Conditions
Cirrhosis, Liver
Interventions
Drug: Propofol
Drug: Midazolam
First Posted Date
2018-01-02
Last Posted Date
2018-08-27
Lead Sponsor
Sherief Abd-Elsalam
Target Recruit Count
100
Registration Number
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Locations
🇪🇬

Sherief Abd-Elsalam, Tanta, Egypt

Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane

Not Applicable
Completed
Conditions
Blood Loss, Surgical
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Interventions
Drug: Sevoflurane
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First Posted Date
2017-12-20
Last Posted Date
2021-02-25
Lead Sponsor
University of Sao Paulo General Hospital
Target Recruit Count
30
Registration Number
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Locations
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Hospital das Clínicas - Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil

EEG Analysis During Light Propofol Sedation

Phase 1
Recruiting
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Electroencephalography
Interventions
Drug: Propofol
First Posted Date
2017-12-05
Last Posted Date
2023-02-16
Lead Sponsor
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Target Recruit Count
30
Registration Number
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Locations
🇫🇷

Department of Anesthesiology and Critical Care Medicine - University Hospital of Nancy, Nancy, France

Neuroimaging of Anesthetic Modulation of Human Consciousness

Phase 4
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Conditions
Healthy
Interventions
Drug: Propofol
First Posted Date
2017-12-05
Last Posted Date
2020-08-18
Lead Sponsor
University of Michigan
Target Recruit Count
30
Registration Number
NCT03361605
Locations
🇺🇸

Michigan Medicine - University of Michigan, Ann Arbor, Michigan, United States

The Effects of Different Anesthetics on Functional Connectivity

Not Applicable
Recruiting
Conditions
Sedation
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Drug: Propofol
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First Posted Date
2017-11-17
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2024-08-01
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Beijing Tian Tan Hospital, Beijing, China

How Different Sedatives Affect Hip Fracture Patient's Postoperative Delirium

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Conditions
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Drug: Dexmedetomidine Hydrochloride
Drug: Propofol
First Posted Date
2017-11-17
Last Posted Date
2017-12-13
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
1000
Registration Number
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The Effect of Propofol or Sevoflurane on Renal Function

Phase 4
Completed
Conditions
Anesthesia
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Interventions
Procedure: Back Surgery
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2017-11-08
Last Posted Date
2021-04-02
Lead Sponsor
Uppsala University
Target Recruit Count
37
Registration Number
NCT03336801
Locations
🇸🇪

Akademiska sjukhuset, Centraloperation, Uppsala, Sweden

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