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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Sevoflurane, Propofol and Desflurane on POD/POCD

Conditions
Propofol
Sevoflurane
Desflurane
Interventions
Drug: Sevoflurane
Drug: Propofol
Drug: Desflurane
First Posted Date
2017-10-31
Last Posted Date
2020-10-22
Lead Sponsor
Shanghai 10th People's Hospital
Target Recruit Count
300
Registration Number
NCT03326960
Locations
🇨🇳

Shanghai 10th People's Hospital, Shanghai, Shanghai, China

The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery

Phase 1
Completed
Conditions
End Stage Renal Disease
Hemodialysis Complication
Interventions
Device: Sevoflurane
Drug: Propofol
First Posted Date
2017-10-17
Last Posted Date
2021-09-05
Lead Sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Target Recruit Count
47
Registration Number
NCT03311581
Locations
🇨🇳

Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Evaluation of Automated Propofol Delivery in Patients Undergoing Thoracic Surgery

Phase 4
Completed
Conditions
Thoracic Diseases
Surgery
Interventions
Drug: Propofol
First Posted Date
2017-10-11
Last Posted Date
2019-07-02
Lead Sponsor
Dr Nitin Sethi
Target Recruit Count
30
Registration Number
NCT03307551
Locations
🇮🇳

Sir Ganga Ram Hospital, New Delhi, Delhi, India

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

Phase 4
Completed
Conditions
Unconsciousness
Consciousness
Interventions
Drug: Dexmedetomidine
Drug: Ketamine
Drug: Propofol
Drug: Midazolam
First Posted Date
2017-09-15
Last Posted Date
2023-04-13
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
35
Registration Number
NCT03284307
Locations
🇺🇸

UW Hospital and Clinics, Madison, Wisconsin, United States

Deep Brain Stimulation (DBS) Sedation

Phase 4
Terminated
Conditions
Brain
Sedation
Interventions
Drug: Propofol
Drug: Dexmedetomidine
Drug: Remifentanil
First Posted Date
2017-09-14
Last Posted Date
2024-07-05
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
20
Registration Number
NCT03283150
Locations
🇺🇸

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Phase 4
Withdrawn
Conditions
Anesthesia
Interventions
Drug: Propofol
First Posted Date
2017-09-14
Last Posted Date
2017-09-14
Lead Sponsor
Brasilia University Hospital
Registration Number
NCT03283410

Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery

Not Applicable
Completed
Conditions
Surgery
Interventions
Drug: Propofol
Drug: Sevoflurane
First Posted Date
2017-08-28
Last Posted Date
2022-06-30
Lead Sponsor
Taichung Veterans General Hospital
Target Recruit Count
78
Registration Number
NCT03263078
Locations
🇨🇳

Taichung Veterans General Hospital, Taichung, Taiwain, Taiwan

Intraoperative Sedatives and Postoperative Deilirium

Not Applicable
Completed
Conditions
Lower Extremity Problem
Delirium
Propofol
Dexmedetomidine
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2017-08-16
Last Posted Date
2022-07-11
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
748
Registration Number
NCT03251651
Locations
🇰🇷

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Responsiveness Index Versus the RASS Based Method for Adjusting Sedation in Critically Ill Patients

Not Applicable
Completed
Conditions
Critical Illness
Interventions
Drug: Propofol
First Posted Date
2017-08-15
Last Posted Date
2019-08-15
Lead Sponsor
Helsinki University Central Hospital
Target Recruit Count
32
Registration Number
NCT03250481
Locations
🇫🇮

HelsinkiUCH, Helsinki, Finland

Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery

Conditions
Cardiovascular Surgical Procedure
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2017-07-31
Last Posted Date
2020-08-06
Lead Sponsor
Coordinación de Investigación en Salud, Mexico
Target Recruit Count
40
Registration Number
NCT03233815
Locations
🇲🇽

Hospital de cardiología, Ciudad de mexico, Cdmx, Mexico

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