Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients

Phase 4

Completed

Conditions: Acute Subdural Hematoma

Interventions: Drug: Isoflurane
Drug: Propofol

First Posted Date: 2017-05-09

Last Posted Date: 2019-02-26

Lead Sponsor: Jawaharlal Institute of Postgraduate Medical Education & Research

Target Recruit Count: 90

Registration Number: NCT03146104

Locations: 🇮🇳
Preethi.J, Puducherry, India

Comparison Between IV Propofol and Propofol/ Fentanyl Anesthesia on Patients Stress Response

Phase 2

Conditions: Stress

Interventions: Drug: Propofol
Drug: Fentanyl

First Posted Date: 2017-05-08

Last Posted Date: 2017-05-08

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT03143933

Locations: 🇪🇬
Kasr Al Aini, Cairo, Egypt

Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy

Phase 4

Completed

Conditions: Colonoscopy

Interventions: Drug: Dexmedetomidine
Other: Saline placebo
Drug: Propofol

First Posted Date: 2017-05-03

Last Posted Date: 2019-07-29

Lead Sponsor: State University of New York - Downstate Medical Center

Target Recruit Count: 122

Registration Number: NCT03139279

Locations: 🇺🇸
SUNY Downstate Medical Center, Brooklyn, New York, United States

Preoperative Anxiety at Oocyte Retrieval

Not Applicable

Completed

Conditions: Infertility, Female
Anesthesia Awareness
Anxiety State

Interventions: Device: Monitoring brain function
Drug: propofol

First Posted Date: 2017-05-01

Last Posted Date: 2017-05-01

Lead Sponsor: Trakya University

Target Recruit Count: 131

Registration Number: NCT03134651

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

Phase 4

Conditions: Epigenetics

Interventions: Drug: Sufentanil
Drug: dexmedetomidine
Drug: propofol
Drug: Rocuronium
Drug: sevoflurane
Drug: remifentanil
Drug: Parecoxib

First Posted Date: 2017-05-01

Last Posted Date: 2017-05-01

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 100

Registration Number: NCT03135795

Locations: 🇨🇳
Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China