Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Sevoflurane in Chronic Obstructive Pulmonary Disease Exacerbation

Not Applicable

Terminated

Conditions: Invasive Mechanical Ventilation
COPD Exacerbation

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2018-03-09

Last Posted Date: 2021-12-28

Lead Sponsor: University Hospital, Montpellier

Target Recruit Count: 16

Registration Number: NCT03460015

Locations: 🇫🇷
University hospital, Montpellier, Hérault, France

Propofol Spinal Procedural Sedation for Cesarean Section

Not Applicable

Completed

Conditions: Patient Compliance

Interventions: Drug: propofol

First Posted Date: 2018-02-19

Last Posted Date: 2020-09-18

Lead Sponsor: Mansoura University

Target Recruit Count: 228

Registration Number: NCT03437980

Locations: 🇪🇬
Delta Hospital, Mansourah, Dakahlya, Egypt
🇪🇬
Mansoura University Hospital, Mansourah, Dakahlya, Egypt
🇪🇬
Zagazig University Hospital, Zagazig, Sharkya, Egypt

Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy

Phase 4

Completed

Conditions: Post-operative Nausea and Vomiting
Laparoscopic Sleeve Gastrectomy

Interventions: Drug: Aprepitant 80 mg Oral Capsule
Drug: scopolamine transdermal
Procedure: Total intravenous anesthesia
Drug: Dexamethasone
Drug: Ondansetron
Drug: Reglan
Drug: Sevoflurane
Drug: Compazine
Drug: Desflurane
Drug: Sugammadex
Drug: Propofol
Drug: dexmedetomidine
Drug: Fentanyl

First Posted Date: 2018-02-15

Last Posted Date: 2024-02-14

Lead Sponsor: Stony Brook University

Target Recruit Count: 83

Registration Number: NCT03435003

Locations: 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States

The Association Between Telomere Length and Propofol Dose in Anesthesia-induction

Not Applicable

Conditions: General Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2018-02-12

Last Posted Date: 2018-02-12

Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Target Recruit Count: 100

Registration Number: NCT03429309

Locations: 🇨🇳
Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, China

Time to Peak Effect of Propofol in Children

Phase 4

Completed

Conditions: Propofol
Child

Interventions: Drug: Propofol

First Posted Date: 2018-02-08

Last Posted Date: 2019-01-30

Lead Sponsor: University Hospital, Basel, Switzerland

Target Recruit Count: 48

Registration Number: NCT03426462

Locations: 🇨🇭
Universitäts Kinderspital beider Basel, Basel, Switzerland

Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application

Not Applicable

Conditions: Anesthesia

Interventions: Drug: Saline Solution
Drug: Rocuronium Bromide
Drug: Fentanyl
Drug: Propofol
Procedure: cystoscopy

First Posted Date: 2018-02-07

Last Posted Date: 2018-06-13

Lead Sponsor: TC Erciyes University

Target Recruit Count: 96

Registration Number: NCT03424356

Locations: 🇹🇷
Erciyes University, Kayseri, Turkey

Study of Remimazolam Tosilate in Patients Undergoing Diagnostic Upper GI Endoscopy

Phase 3

Completed

Conditions: Sedation

Interventions: Drug: Remimazolam Tosilate
Drug: Propofol

First Posted Date: 2018-02-07

Last Posted Date: 2018-02-12

Lead Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Target Recruit Count: 378

Registration Number: NCT03425474

Locations: 🇨🇳
Clinical trial Ethnics Committee of Peking Union Medical College Hospital, Beijing, Beijing, China

Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection

Not Applicable

Conditions: General Anesthesia

Interventions: Drug: Propofol

First Posted Date: 2018-02-05

Last Posted Date: 2021-06-09

Lead Sponsor: Zhongyuan Xu

Target Recruit Count: 60

Registration Number: NCT03422315

Locations: 🇨🇳
Nanfang Hospital，Southern Medical University, Guangzhou, Guangdong, China

Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Phase 4

Completed

Conditions: Obesity
Anesthesia

Interventions: Drug: Desflurane Inhalant Product
Drug: Propofol

First Posted Date: 2018-01-31

Last Posted Date: 2018-02-09

Lead Sponsor: Centre Hospitalier Universitaire Saint Pierre

Target Recruit Count: 40

Registration Number: NCT03417518

Sedation Strategies for Diagnostic Bronchoscopy

Not Applicable

Terminated

Conditions: Sedation
Bronchoscopy

Interventions: Drug: Midazolam
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Remifentanil
Drug: Propofol

First Posted Date: 2018-01-23

Last Posted Date: 2019-06-12

Lead Sponsor: Changhai Hospital

Target Recruit Count: 28

Registration Number: NCT03406533

Locations: 🇨🇳
Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China

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