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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children

Not Applicable
Conditions
Homocysteine
Sevoflurane
Cochlear Hearing Loss
Propofol
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2018-07-23
Last Posted Date
2018-07-23
Lead Sponsor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Target Recruit Count
80
Registration Number
NCT03595163
Locations
🇨🇳

Shanghai ninth people's hospital, Shanghai, China

Laryngeal Mask in Upper Gastrointestinal Procedures

Not Applicable
Terminated
Conditions
Anesthesia
Airway Device
C.Surgical Procedure; Gastrointestinal
Interventions
Device: Sedation with Gastro Cuff Pilot Laryngeal Mask
Drug: Propofol
First Posted Date
2018-06-26
Last Posted Date
2019-04-16
Lead Sponsor
Ospedale San Raffaele
Target Recruit Count
16
Registration Number
NCT03567928
Locations
🇮🇹

San Raffaele Hospital, Milan, Milano, Italy

Modeling and Closed-loop Control of Depth of Anaesthesia

Recruiting
Conditions
The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation
Interventions
Drug: Propofol
First Posted Date
2018-06-26
Last Posted Date
2023-12-18
Lead Sponsor
University of Ljubljana
Target Recruit Count
50
Registration Number
NCT03569839
Locations
🇸🇮

University Medical Centre Ljubljana, Ljubljana, Slovenia

Effect of Anaesthesia on ER Stress in Cancer Patients

Not Applicable
Completed
Conditions
Endoplasmic Reticulum Stress
Interventions
Drug: Propofol
Drug: Sevoflurane
First Posted Date
2018-06-19
Last Posted Date
2021-10-15
Lead Sponsor
Konkuk University Medical Center
Target Recruit Count
53
Registration Number
NCT03561831
Locations
🇰🇷

Konkuk University Medical Center, Seoul, Korea, Republic of

Automatic Remifentanil Administration Guided by ANI During Propofol Anesthesia

Not Applicable
Completed
Conditions
Nociceptive Pain
Surgical Procedure, Unspecified
Interventions
Device: remifentanil pK/pD target administration device
Device: ANI-REMI-loop
Drug: Remifentanil
Drug: Propofol
Device: ANI monitor
First Posted Date
2018-06-14
Last Posted Date
2022-12-16
Lead Sponsor
University Hospital, Lille
Target Recruit Count
52
Registration Number
NCT03556696
Locations
🇫🇷

Hôpital Roger Salengro, CHU, Lille, France

Airway Complications After LMA in Children

Not Applicable
Completed
Conditions
Anesthesia Recovery
Interventions
Drug: Propofol
Drug: Sevoflurane
First Posted Date
2018-06-12
Last Posted Date
2021-08-24
Lead Sponsor
American University of Beirut Medical Center
Target Recruit Count
135
Registration Number
NCT03553082
Locations
🇱🇧

American University of Beirut, Beirut, Lebanon

Evaluating the Effects of Propofol vs. Dexmedetomidine

Conditions
Sedative Adverse Reaction
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2018-06-11
Last Posted Date
2019-07-24
Lead Sponsor
Children's Healthcare of Atlanta
Target Recruit Count
60
Registration Number
NCT03552146
Locations
🇺🇸

Children's Healthcare of Atlanta, Atlanta, Georgia, United States

Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH

Phase 2
Completed
Conditions
Conscious Sedation
Interventions
Drug: Magnesium sulphate
Drug: Fentanyl
Drug: Propofol
First Posted Date
2018-06-07
Last Posted Date
2018-12-04
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
34
Registration Number
NCT03548493
Locations
🇪🇬

Kasr El Aini Hospital, Cairo, Egypt

Automated Anesthesia Guided by the Conox Monitor for Surgery

Not Applicable
Terminated
Conditions
Anesthesia, General
Interventions
Drug: Propofol
Device: Closed loop anesthesia
Drug: Remifentanil
First Posted Date
2018-05-30
Last Posted Date
2021-11-05
Lead Sponsor
CMC Ambroise Paré
Target Recruit Count
62
Registration Number
NCT03540875
Locations
🇫🇷

Service d'Anesthésie, Hôpital Foch, Suresnes, Ile De France, France

🇫🇷

Service d'Anesthésie du Centre Clinical, Soyaux, Poitou-Charentes, France

🇫🇷

Service d'Anesthésie Réanimation Chirurgicale, CHU Besançon, Besançon, Bourgogne-Franche-Comté, France

Opioid-Free Shoulder Arthroplasty

Phase 4
Completed
Conditions
Arthritis;Inflammatory
Opioid Use
Shoulder Osteoarthritis
Avascular Necrosis
Rotator Cuff Tear
Interventions
Drug: Gabapentin
Drug: Celecoxib
Drug: toradol
Drug: acetaminophen
Drug: regional block
Drug: propofol
Drug: IV lidocaine
Drug: rocuronium
Drug: vecuronium
Drug: sevoflurane
Drug: desflurane
First Posted Date
2018-05-30
Last Posted Date
2020-10-14
Lead Sponsor
OrthoCarolina Research Institute, Inc.
Target Recruit Count
86
Registration Number
NCT03540030
Locations
🇺🇸

OrthoCarolina Research Institute, Charlotte, North Carolina, United States

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