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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Predictive Model in EEG for Induction and Emergence in Pediatric With Propofol

Terminated
Conditions
Children, Only
Electroencephalography
Anesthesia
Interventions
Device: Electroencephalography
Drug: Propofol
First Posted Date
2018-10-15
Last Posted Date
2022-03-08
Lead Sponsor
Victor Contreras, MSN
Target Recruit Count
1
Registration Number
NCT03705338
Locations
🇨🇱

Victor Contreras, Santiago, Región Metropolitana, Chile

Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium

Not Applicable
Conditions
Postoperative Delirium
General Anesthetic Drug Adverse Reaction
Elderly Patient
Interventions
Drug: Propofol
Drug: Sevoflurane
Drug: Remifentanil automatic
Drug: Remifentanil manual
First Posted Date
2018-10-15
Last Posted Date
2018-10-18
Lead Sponsor
Centre Clinical, France
Target Recruit Count
1000
Registration Number
NCT03705728
Locations
🇫🇷

Centre Clinical, Soyaux, Charente, France

Development of pk/pd Model of Propofol in Patients With Severe Burns

Terminated
Conditions
Anesthesia
Burned
Operative Wound
Interventions
Drug: Propofol
Device: BIS
First Posted Date
2018-10-12
Last Posted Date
2022-03-08
Lead Sponsor
Victor Contreras, MSN
Target Recruit Count
15
Registration Number
NCT03704285
Locations
🇨🇱

Victor Contreras, Santiago, Región Metropolitana, Chile

Effect of Anesthetic Agents on Optic Nerve Sheath Diameter

Not Applicable
Completed
Conditions
Uterus Myoma
Uterine Cancer
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2018-10-10
Last Posted Date
2020-09-04
Lead Sponsor
Hallym University Kangnam Sacred Heart Hospital
Target Recruit Count
42
Registration Number
NCT03701529
Locations
🇰🇷

Kangnam Sungshim Hospital, Seoul, Korea, Republic of

A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population

Completed
Conditions
Acute Kidney Injury
Hypotension
Anesthesia; Adverse Effect
Interventions
Drug: Propofol
First Posted Date
2018-10-09
Last Posted Date
2019-01-24
Lead Sponsor
Yale University
Target Recruit Count
541
Registration Number
NCT03699696
Locations
🇺🇸

Yale New Haven Health System, New Haven, Connecticut, United States

A Phase IIa Study Investigating the Tolerance, Efficacy and Safety of HSK3486

Phase 2
Completed
Conditions
Induction of General Anaesthesia
Interventions
Drug: HSK3486
Drug: Propofol
First Posted Date
2018-10-09
Last Posted Date
2018-10-09
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
114
Registration Number
NCT03698617
Locations
🇨🇳

The 2nd Affiliated Hospital of WMU, Wenzhou, Zhejiang, China

Neural and Antidepressant Effects of Propofol

Phase 2
Active, not recruiting
Conditions
Treatment Resistant Depression
Interventions
Drug: Propofol
First Posted Date
2018-09-25
Last Posted Date
2024-05-07
Lead Sponsor
University of Utah
Target Recruit Count
48
Registration Number
NCT03684447
Locations
🇺🇸

University Neuropsychiatric Institute, Salt Lake City, Utah, United States

Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.

Not Applicable
Completed
Conditions
Hallux Valgus
Surgery
Interventions
Device: Virtual reality
Drug: Droleptan
Drug: Propofol
Drug: Sufentanyl
First Posted Date
2018-09-19
Last Posted Date
2019-03-26
Lead Sponsor
Clinique Saint Jean, France
Target Recruit Count
60
Registration Number
NCT03677323
Locations
🇫🇷

Clinique Saint Jean, Montpellier, France

A Phase III Study Evaluating The Efficacy and Safety of HSK3486 for Sedation or Anesthesia

Phase 3
Completed
Conditions
Sedation or Anesthesia
Interventions
Drug: HSK3486
Drug: Propofol
First Posted Date
2018-09-17
Last Posted Date
2019-07-05
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
280
Registration Number
NCT03674008
Locations
🇨🇳

West China Hospital, Sichuan University, Changde, China

Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia

Phase 3
Completed
Conditions
General Anaesthesia
Interventions
Drug: Remimazolam
Drug: Propofol
Drug: Fentanyl
Drug: Rocuronium bromide
First Posted Date
2018-09-13
Last Posted Date
2018-09-13
Lead Sponsor
R-Pharm
Target Recruit Count
150
Registration Number
NCT03669484
Locations
🇷🇺

SBHI City Clinical Hospital №1 n.a. N.I. Pirogov, Moscow, Russian Federation

🇷🇺

FSBI Central Clinical Hospital and Polyclinic of Adminisatration of the President of the Russian Federation, Moscow, Russian Federation

🇷🇺

SBHI Moscow Clinical Research and Practical center of Department of Healthcare of the city of Moscow, Moscow, Russian Federation

and more 3 locations
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