Propofol
- Generic Name
- Propofol
- Brand Names
- Diprivan
- Drug Type
- Small Molecule
- Chemical Formula
- C12H18O
- CAS Number
- 2078-54-8
- Unique Ingredient Identifier
- YI7VU623SF
- Background
Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
- Indication
Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
- Associated Conditions
- -
- Associated Therapies
- Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
- Conditions
- Ischemia Reperfusion Injury
- Interventions
- First Posted Date
- 2018-12-11
- Last Posted Date
- 2019-12-12
- Lead Sponsor
- University of Chile
- Target Recruit Count
- 16
- Registration Number
- NCT03772054
- Locations
- 🇨🇱
Hospital Clínico de la Universidad de Chile, Independencia, Santiago, Chile
The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness
- Conditions
- Propofol
- Interventions
- First Posted Date
- 2018-12-03
- Last Posted Date
- 2018-12-03
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT03762538
Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
- Conditions
- Pain, PostoperativeObesity
- Interventions
- Drug: RemifentanilDrug: DexmedetomidineBehavioral: Person-centred care (PCC)Drug: DesfluraneDrug: PropofolDrug: EsketamineDrug: OxycodoneDrug: LidocaineDevice: Transcutaneous Nerve Stimulation (TENS)
- First Posted Date
- 2018-11-28
- Last Posted Date
- 2024-10-14
- Lead Sponsor
- Göteborg University
- Target Recruit Count
- 220
- Registration Number
- NCT03756961
- Locations
- 🇸🇪
Lindesberg Hospital, Lindesberg, Region Örebro, Sweden
🇸🇪Sahlgrenska University hospital/ Östra hopsital, Gothenburg, VG, Sweden
Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation
- Conditions
- Transcatheter Aortic Valve ReplacementProcedural Sedation
- Interventions
- First Posted Date
- 2018-11-20
- Last Posted Date
- 2023-05-10
- Lead Sponsor
- University Medical Centre Ljubljana
- Target Recruit Count
- 70
- Registration Number
- NCT03747432
- Locations
- 🇸🇮
UMC Ljubljana, Ljubljana, Slovenia
The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children
- Conditions
- Anesthetic Toxicity
- Interventions
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2018-11-19
- Lead Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- Target Recruit Count
- 40
- Registration Number
- NCT03746340
- Locations
- 🇨🇳
Shanghai Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China
A Study Evaluating the Safety and Pharmacokinetics/Pharmacodynamics of HSK3486
- First Posted Date
- 2018-11-19
- Last Posted Date
- 2020-01-09
- Lead Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
- Target Recruit Count
- 16
- Registration Number
- NCT03745625
- Locations
- 🇨🇳
West China Hospital，Sichuan University, Chengdu, China
Rectal Acetaminophen Use During Oocyte Retrievals to Reduce Post-Operative Opioid Utilization
- First Posted Date
- 2018-11-06
- Last Posted Date
- 2021-06-18
- Lead Sponsor
- University of South Florida
- Target Recruit Count
- 4
- Registration Number
- NCT03732469
- Locations
- 🇺🇸
University of South Florida, Tampa, Florida, United States
Delirium Reduction by Volatile Anesthesia in Cardiac Surgery
- First Posted Date
- 2018-11-02
- Last Posted Date
- 2024-01-16
- Lead Sponsor
- Meshalkin Research Institute of Pathology of Circulation
- Target Recruit Count
- 353
- Registration Number
- NCT03729011
- Locations
- 🇷🇺
Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation
🇷🇺Saint Petersburg State University Hospital, Saint Petersburg, Russian Federation
🇷🇺Meshalkin Research Institute of Pathology of Circulation, Novosibirsk, Russian Federation
Memory Priming in General Anesthesia
- Conditions
- Unconscious (Psychology)
- Interventions
- Behavioral: Abstract primingBehavioral: ControlsBehavioral: Concrete primingDrug: PropofolDrug: Sevoflurane
- First Posted Date
- 2018-11-01
- Last Posted Date
- 2019-09-06
- Lead Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Target Recruit Count
- 102
- Registration Number
- NCT03727464
- Locations
- 🇮🇹
Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
A Study Evaluating the Efficacy and Safety of HSK3486
- Conditions
- Sedation and Anesthesia for Adult Colonoscopy Procedures
- Interventions
- Drug: HSK3486Drug: Propofol
- First Posted Date
- 2018-10-17
- Last Posted Date
- 2018-10-18
- Lead Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
- Target Recruit Count
- 94
- Registration Number
- NCT03709056
- Locations
- 🇨🇳
Shanghai Fengxian District Central Hospital, Shanghai, China
🇨🇳West China Hospital, Sichuan University, Changde, China
🇨🇳The Third Xiangya Hospital of Central South University, Changsha, China
Drug Development Updates
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