Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.

Phase 4

Completed

Conditions: Anesthesia, General
Anesthesia, Intravenous
Hemodynamics Instability

Interventions: Drug: Propofol

First Posted Date: 2019-03-04

Last Posted Date: 2020-06-17

Lead Sponsor: Helse Fonna

Target Recruit Count: 68

Registration Number: NCT03861364

Locations: 🇳🇴
Kirurgisk Klinikk-Anestesi, Haugesund, Rogaland, Norway

Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery

Phase 2

Completed

Conditions: Monitored Anesthesia Care

Interventions: Drug: Magnesium Sulphate
Drug: Fentanyl
Drug: Propofol

First Posted Date: 2019-02-26

Last Posted Date: 2021-04-13

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 32

Registration Number: NCT03854812

Locations: 🇪🇬
Kasr Alaini Hospital, Cairo, Egypt

Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium

Not Applicable

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Ketamine
Drug: Oxytocin
Drug: Etomidate
Drug: Propofol

First Posted Date: 2019-02-25

Last Posted Date: 2022-10-25

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 33

Registration Number: NCT03852797

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

The Deep Sedation for Ablation Study

Phase 4

Completed

Conditions: Sedation
Propofol
Dexmedetomidine
Atrial Fibrillation
Ablation

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2019-02-19

Last Posted Date: 2021-01-25

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 160

Registration Number: NCT03844841

Locations: 🇨🇭
Department of Cardiology, University Hospital Inselspital Bern, Bern, Bern (Kanton), Switzerland

Regional Anesthesia Versus General Anesthesia

Not Applicable

Completed

Conditions: Postoperative Pain
Anesthesia

Interventions: Drug: Midazolam
Drug: Sufentanil
Drug: Bupivacaine
Drug: Propofol
Drug: Rocuronium
Drug: Sevoflurane

First Posted Date: 2019-02-05

Last Posted Date: 2019-07-15

Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Target Recruit Count: 28

Registration Number: NCT03830086

Locations: 🇮🇹
Cardiothoracic and Vascular Anesthesia and Intensive Care, S. OrsolaMalpighi University Hospital, Bologna, BO, Italy
🇮🇹
Gynecology and Physiopathology of Human Reproductive Unit, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, BO, Italy