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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Modeling and Application of Triple Drug Response Surface Models

Completed
Conditions
Drug Interactions
Pharmacodynamics
Interventions
Other: Bispectral index (BIS) and analgesia nociception index (ANI)
Drug: Fentanyl
Drug: alfentanil
Drug: Propofol
Drug: midazolam
Drug: sevoflurane
First Posted Date
2019-01-23
Last Posted Date
2022-07-20
Lead Sponsor
Taipei Veterans General Hospital, Taiwan
Target Recruit Count
100
Registration Number
NCT03813875
Locations
🇨🇳

Taipei Veterans General Hospital, Taipei, Taiwan

A Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion for the Induction of General Anesthesia in Elective Surgery Subjects

Phase 3
Completed
Conditions
Induction of Anesthesia
Interventions
Drug: HSK3486
Drug: Propofol
First Posted Date
2019-01-18
Last Posted Date
2019-09-13
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
178
Registration Number
NCT03808844
Locations
🇨🇳

West China Hospital of Sichuan University, Chengdu, China

Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?

Not Applicable
Completed
Conditions
Anesthesia
Interventions
Drug: Ketamine
Drug: Fentanyl
Drug: Propofol
Drug: Cisatracurium
Drug: Lidocaine
First Posted Date
2019-01-16
Last Posted Date
2019-01-16
Lead Sponsor
Ain Shams University
Target Recruit Count
120
Registration Number
NCT03806374
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

Not Applicable
Completed
Conditions
Colorectal Cancer
Interventions
Other: Quadratus lumborum block
Other: Erector spinae plane block
Drug: Propofol
Drug: Fentanyl NCS
Drug: Atracurium Injectable Product
Other: Endotracheal intubation
Drug: Anesthesia Maintenance
Drug: Muscle Relaxation
First Posted Date
2019-01-14
Last Posted Date
2020-04-03
Lead Sponsor
Mansoura University
Target Recruit Count
68
Registration Number
NCT03803267
Locations
🇪🇬

Amer A Attieh, Mansourah, DK, Egypt

Ketamine Versus Propofol Effect on the Immune-mediatory Response for Abdominal Surgery

Not Applicable
Conditions
Major Abdominal Surgery
Interventions
Drug: Propofol
Drug: Ketamine
First Posted Date
2019-01-04
Last Posted Date
2019-01-07
Lead Sponsor
Mansoura University Hospital
Target Recruit Count
36
Registration Number
NCT03793075

Maintenance of Anaesthesia With Sevoflurane Versus Propofol and the Occurrence of Postoperative Headache.

Not Applicable
Conditions
Headache
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2018-12-28
Last Posted Date
2019-11-19
Lead Sponsor
Attikon Hospital
Target Recruit Count
130
Registration Number
NCT03789370
Locations
🇬🇷

2nd Department of Anesthesiology, Attikon Hospital, 1 Rimini str., Athens, Greece

Epigenetics in PostOperative Pediatric Emergence Delirium

Not Applicable
Completed
Conditions
Emergence Delirium
Postoperative Complications
DNA Methylation
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2018-12-26
Last Posted Date
2022-01-20
Lead Sponsor
University of Sao Paulo
Target Recruit Count
175
Registration Number
NCT03787849
Locations
🇧🇷

Instituto da Criança do Hospital das Clinicas da FMUSP, São Paulo, Brazil

Study of Remimazolam Tosilate in Patients Undergoing Colonoscopy

Phase 3
Completed
Conditions
Sedation
Interventions
Drug: Propofol
Drug: Remimazolam Tosilate
First Posted Date
2018-12-19
Last Posted Date
2018-12-19
Lead Sponsor
Jiangsu HengRui Medicine Co., Ltd.
Target Recruit Count
388
Registration Number
NCT03779061
Locations
🇨🇳

Clinical trial Ethnics Committee of Peking Union Medical College Hospital, Beijing, Beijing, China

Dexmedetomidine Versus Propofol in Conjunction With Regional Block for Shoulder Arthroscopy

Phase 4
Completed
Conditions
Hemodynamic
Sedation
Satisfaction, Personal
Interventions
Procedure: Shoulder Arthroscopy
Procedure: Regional Block
Drug: Dexmedetomidine
Drug: Propofol
Diagnostic Test: BIS
First Posted Date
2018-12-14
Last Posted Date
2018-12-17
Lead Sponsor
Saint-Joseph University
Target Recruit Count
60
Registration Number
NCT03775876
Locations
🇱🇧

Hotel Dieu de France Hospital, Beirut, Lebanon

A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients

Phase 2
Completed
Conditions
Colonoscopy
Interventions
Drug: HSK3486
Drug: Propofol
First Posted Date
2018-12-12
Last Posted Date
2018-12-13
Lead Sponsor
Sichuan Haisco Pharmaceutical Group Co., Ltd
Target Recruit Count
64
Registration Number
NCT03773042
Locations
🇨🇳

West China Hospital, Sichuan University, Chengdu, Sichuan, China

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