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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Conscious Sedation for Cataract Operations Under Topical Anaesthesia

Phase 2
Completed
Conditions
Conscious Sedation
Interventions
Drug: Nalbuphine
Drug: Propofol
Drug: Dexmedetomidine
Drug: Benoxinate Hydrochloride 0.4% Eye Drops
First Posted Date
2019-05-01
Last Posted Date
2021-01-08
Lead Sponsor
Menoufia University
Target Recruit Count
100
Registration Number
NCT03933280
Locations
🇪🇬

Faculty of Medicine, Cairo, Shebin El-kom, Egypt

Synchronous Effect of Anesthetics on fMRI, EEG and Clinical Responses

Phase 1
Completed
Conditions
Sedative Overdose
Interventions
Drug: Propofol
Drug: Remifentanil
First Posted Date
2019-04-26
Last Posted Date
2022-09-30
Lead Sponsor
Parc de Salut Mar
Target Recruit Count
30
Registration Number
NCT03928366
Locations
🇪🇸

Hospital del Mar, Barcelona, Spain

The Neuroprotection Effect of Dexmedetomidine

Not Applicable
Conditions
Dexmedetomidine
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2019-04-25
Last Posted Date
2019-04-25
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
70
Registration Number
NCT03927963

Conscious Sedation for Outpatient Colonoscopy

Phase 2
Completed
Conditions
Conscious Sedation
Interventions
Drug: Dexmedetomidine
Drug: Propofol
Drug: Remifentanil
First Posted Date
2019-04-24
Last Posted Date
2021-01-08
Lead Sponsor
Menoufia University
Target Recruit Count
80
Registration Number
NCT03925779
Locations
🇪🇬

Faculty of Medicine, Cairo, Shebin El-kom, Egypt

Neural and Antidepressant Effects of Propofol (Phase 2)

Phase 2
Withdrawn
Conditions
Treatment Resistant Depression
Interventions
Drug: Diprivan
First Posted Date
2019-04-22
Last Posted Date
2019-12-18
Lead Sponsor
University of Utah
Registration Number
NCT03923361
Locations
🇺🇸

Univeristy Neuropsychiatric Institute, Salt Lake City, Utah, United States

A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery

Phase 3
Completed
Conditions
Anesthesia for Elective Surgery Patients
Interventions
Drug: Remimazolam Tosilate
Drug: Propofol
First Posted Date
2019-04-19
Last Posted Date
2020-05-15
Lead Sponsor
Jiangsu HengRui Medicine Co., Ltd.
Target Recruit Count
330
Registration Number
NCT03921775
Locations
🇨🇳

Peking Union Medical College Hospital, Beijing, Beijing, China

Re-craniotomy and Complications After Elective Neurosurgery

Completed
Conditions
Brain Neoplasms
Brain Tumor
Brain Cancer
Brain Metastases
Interventions
Drug: Propofol
First Posted Date
2019-04-10
Last Posted Date
2019-04-12
Lead Sponsor
Chiang Mai University
Target Recruit Count
439
Registration Number
NCT03910556

Comparison of Postoperative Outcomes Between Surgeries Anaesthetized With Propofol and Inhalational Anaesthetics

Completed
Conditions
Acute Pain
Interventions
Drug: inhalation anaesthetics
Drug: Propofol
First Posted Date
2019-03-15
Last Posted Date
2023-05-10
Lead Sponsor
The University of Hong Kong
Target Recruit Count
3922
Registration Number
NCT03875872
Locations
🇭🇰

The University of Hong Kong, Hong Kong, Hong Kong

Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine.

Phase 4
Completed
Conditions
Anesthesia, General
Anesthesia, Intravenous
Hemodynamic Instability
Interventions
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Sodium chloride
Drug: Propofol
Drug: Remifentanil
First Posted Date
2019-03-06
Last Posted Date
2024-10-04
Lead Sponsor
Helse Fonna
Target Recruit Count
128
Registration Number
NCT03864094
Locations
🇳🇴

Helse Fonna, Haugesund Sykehus, Haugesund, Norway

Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.

Phase 4
Completed
Conditions
Anesthesia, General
Anesthesia, Intravenous
Hemodynamics Instability
Interventions
Drug: Propofol
First Posted Date
2019-03-04
Last Posted Date
2020-06-17
Lead Sponsor
Helse Fonna
Target Recruit Count
68
Registration Number
NCT03861364
Locations
🇳🇴

Kirurgisk Klinikk-Anestesi, Haugesund, Rogaland, Norway

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