Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Ketamine Co-induction for Patients With Major Depressive Disorder

Phase 4

Conditions: Depression
Anesthesia
Ketamine

Interventions: Drug: Propofol
Drug: Ketamine Hydrochloride
Drug: Fentanyl

First Posted Date: 2018-09-11

Last Posted Date: 2018-09-13

Lead Sponsor: University of Saskatchewan

Target Recruit Count: 50

Registration Number: NCT03666494

Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery

Phase 3

Completed

Conditions: Anesthesia, Intravenous

Interventions: Drug: Remimazolam
Drug: Propofol

First Posted Date: 2018-09-07

Last Posted Date: 2020-05-28

Lead Sponsor: Paion UK Ltd.

Target Recruit Count: 469

Registration Number: NCT03661489

Locations: 🇩🇪
University of Erlangen, Erlangen, Bavaria, Germany

Quality of Recovery After Robotic Surgery

Not Applicable

Completed

Conditions: Patients Undergoing Robotic Surgery

Interventions: Drug: PROPOFOL
Drug: Desflurane

First Posted Date: 2018-09-06

Last Posted Date: 2023-05-31

Lead Sponsor: Nitin Sethi, DNB

Target Recruit Count: 120

Registration Number: NCT03659539

Locations: 🇮🇳
Sir Ganga Ram Hospital, New Delhi, Delhi, India

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

Phase 3

Completed

Conditions: Critical Illness

Interventions: Drug: Propofol
Drug: Dexmedetomidine
Drug: Clonidine

First Posted Date: 2018-08-31

Last Posted Date: 2024-10-03

Lead Sponsor: University of Edinburgh

Target Recruit Count: 1437

Registration Number: NCT03653832

Locations: 🇬🇧
Belfast Health & Social Care Trust, Belfast, United Kingdom
🇬🇧
South Eastern Health and Social Trust, Belfast, United Kingdom
🇬🇧
University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

and more 35 locations