Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Perioperative Analgesic Modalities for Breast Cancer Surgeries
- Conditions
- Interventions
- First Posted Date
- 2020-01-30
- Last Posted Date
- 2020-07-21
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 75
- Registration Number
- NCT04248608
- Locations
- 🇪🇬
Department of anesthesia and pain medicine. National Cancer Institute, Cairo, Egypt
Multimodal Pain Study in Free Flap Patients
- Conditions
- Interventions
- First Posted Date
- 2020-01-29
- Last Posted Date
- 2023-08-18
- Lead Sponsor
- University of Kansas Medical Center
- Target Recruit Count
- 30
- Registration Number
- NCT04246697
- Locations
- 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States
Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)
- Conditions
- Interventions
- First Posted Date
- 2020-01-02
- Last Posted Date
- 2024-02-28
- Target Recruit Count
- 190
- Registration Number
- NCT04214834
- Locations
- 🇺🇸
Loma Linda University Medical Center, Loma Linda, California, United States
🇺🇸University of Arizona, Tucson, Arizona, United States
🇺🇸West Virginia University Hospital, Morgantown, West Virginia, United States
Fentanyl Buccal Tablet or Morphine for Exertional Dyspnea in Cancer Patients
- First Posted Date
- 2019-12-05
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 150
- Registration Number
- NCT04188418
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
Pramipexole and Morphine for Renal Colic
- Conditions
- Interventions
- First Posted Date
- 2019-11-13
- Last Posted Date
- 2023-03-08
- Lead Sponsor
- East Carolina University
- Target Recruit Count
- 19
- Registration Number
- NCT04160520
- Locations
- 🇺🇸
Vidant Medical Center ED, Greenville, North Carolina, United States
Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine
- First Posted Date
- 2019-10-24
- Last Posted Date
- 2023-01-12
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 44
- Registration Number
- NCT04138615
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Cordotomy in Reducing Pain in Patients With Advanced Cancer
- Conditions
- Interventions
- First Posted Date
- 2019-10-08
- Last Posted Date
- 2024-10-15
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 42
- Registration Number
- NCT04119037
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
A Relation of Morphine-induced Itch and Pain Processing
- Conditions
- Interventions
- First Posted Date
- 2019-10-04
- Last Posted Date
- 2020-07-08
- Lead Sponsor
- Aalborg University
- Target Recruit Count
- 24
- Registration Number
- NCT04115462
- Locations
- 🇩🇰
Mech-Sense, Medicinsk Gastroenterologisk ambulatorium, Medicineshus, Aalborg Universitetshospitalet,, AAlborg, Nordjylland, Denmark
Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery
- Conditions
- Interventions
- First Posted Date
- 2019-10-01
- Last Posted Date
- 2019-10-01
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Target Recruit Count
- 200
- Registration Number
- NCT04110665
- Locations
- 🇫🇷
CHU de Nimes, Nîmes, France
CHF6563 in Babies With Neonatal Opioid Withdrawal Syndrome
- Conditions
- Interventions
- First Posted Date
- 2019-09-26
- Last Posted Date
- 2023-08-03
- Lead Sponsor
- Chiesi Farmaceutici S.p.A.
- Target Recruit Count
- 7
- Registration Number
- NCT04104646
- Locations
- 🇺🇸
Clinical site 015, Las Vegas, Nevada, United States
🇺🇸Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.