Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Oral Pregabalin Effect to the Intravenous Morphine in Multiple Fracture Ribs

Early Phase 1

Conditions: Fracture; Rib, Multiple

Interventions: Drug: Pregabalin 150mg
Drug: Morphine

First Posted Date: 2018-03-22

Last Posted Date: 2018-03-23

Lead Sponsor: Assiut University

Target Recruit Count: 80

Registration Number: NCT03473093

Effect of Intrathecal Morphine on Chronic Pain After Elective Caesarean Section

Phase 4

Completed

Conditions: Chronic Pain Post-Procedural

Interventions: Drug: Placebo
Drug: Morphine

First Posted Date: 2018-03-02

Last Posted Date: 2021-04-06

Lead Sponsor: B.P. Koirala Institute of Health Sciences

Target Recruit Count: 290

Registration Number: NCT03451695

Locations: 🇳🇵
BP Koirala Institute of Health Sciences (BPKIHS), Dharān Bāzār, Koshi, Nepal

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Morphine Consumption in Lumbar Disc Surgery

Not Applicable

Completed

Conditions: Postoperative Pain Management

Interventions: Drug: Morphine Sulfate
Drug: Intravenous paracetamol
Drug: Intravenous ibuprofen

First Posted Date: 2018-02-19

Last Posted Date: 2018-09-05

Lead Sponsor: Inonu University

Target Recruit Count: 3

Registration Number: NCT03437707

Locations: 🇹🇷
Sedat AKBAS, Malatya, Türkiye-Türkçe, Turkey

Post Operative Pain Control After Pediatric Hip Surgery

Not Applicable

Terminated

Conditions: Post Operative Pain Control
Hip Surgery

Interventions: Procedure: Lumbar Plexus Catheter
Procedure: Lumbar Epidural Catheter
Procedure: Patient Controlled Analgesia
Drug: Fentanyl
Drug: Morphine
Drug: Lorazepam
Drug: Ondansetron
Drug: Diphenhydramine
Drug: Acetaminophen
Drug: Oxycodone
Drug: Ropivacaine

First Posted Date: 2018-02-19

Last Posted Date: 2021-11-02

Lead Sponsor: Seattle Children's Hospital

Target Recruit Count: 42

Registration Number: NCT03435692

Ultrasound Guided QLB III Versus Intrathecal Morphine for Analgesia After Cesarean Section

Phase 4

Completed

Conditions: Block

Interventions: Drug: Quadratus lumborum block
Drug: Morphine

First Posted Date: 2018-02-12

Last Posted Date: 2018-02-14

Lead Sponsor: University Tunis El Manar

Target Recruit Count: 120

Registration Number: NCT03428880

Locations: 🇹🇳
Tunis maternity and neonatology center, minisetry of public health, Tunis, Tunisia
🇹🇳
Tunis maternity and neonatology center,, Tunis, Tunisia

Study of Oral Morphine Sulfate Administration in Pediatric Subjects

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Morphine Sulfate

First Posted Date: 2018-02-12

Last Posted Date: 2019-09-26

Lead Sponsor: West-Ward Pharmaceutical

Target Recruit Count: 51

Registration Number: NCT03429400

Locations: 🇺🇸
Site 105, Sheffield, Alabama, United States

Thoracic Paravertebral Blocks in Open Nephrectomy

Phase 2

Completed

Conditions: Nephrectomy
Analgesia

Interventions: Drug: Ropivacaine
Drug: Morphine

First Posted Date: 2018-02-09

Last Posted Date: 2023-10-13

Lead Sponsor: Asklepieion Voulas General Hospital

Target Recruit Count: 60

Registration Number: NCT03428633

Locations: 🇬🇷
Asklepieion Hospital of Voula, Athens, Greece

Anesthetics and Analgesics in Children

Recruiting

Conditions: Anesthesia
Pain

Interventions: Drug: Ketorolac Tromethamine
Drug: Hydromorphone
Drug: Ketamine
Drug: Oxycodone
Drug: Morphine

First Posted Date: 2018-02-09

Last Posted Date: 2024-01-18

Lead Sponsor: Kanecia Obie Zimmerman

Target Recruit Count: 460

Registration Number: NCT03427736

Locations: 🇺🇸
Baylor College of Medicine, Houston, Texas, United States
🇺🇸
Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, Illinois, United States
🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States

and more 10 locations