Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Multimodal Analgesia in Shoulder Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2018-07-16
- Last Posted Date
- 2021-09-28
- Lead Sponsor
- Rush University Medical Center
- Registration Number
- NCT03586934
- Locations
- 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)
- Conditions
- Interventions
- First Posted Date
- 2018-07-13
- Last Posted Date
- 2019-05-09
- Lead Sponsor
- Mundipharma Pharmaceuticals srl
- Target Recruit Count
- 272
- Registration Number
- NCT03585374
- Locations
- 🇮🇹
Azienda USL Toscana Centro U.O. Centrale Operativa 118, Pistoia, Italy
🇮🇹ATS (Azienda tutela Salute)_Struttura Complessa Centrale Operativa 118, Sassari, SS, Italy
🇮🇹Medicina e Chirurgia di accettazione e di urgenza Humanitas Gradenigo - Presidio Sanitario, Torino, TO, Italy
Multimodal Analgesia in Major Abdominal Pediatric Cancer Surgeries
- Conditions
- Interventions
- First Posted Date
- 2018-07-10
- Last Posted Date
- 2018-07-10
- Lead Sponsor
- National Cancer Institute, Egypt
- Target Recruit Count
- 90
- Registration Number
- NCT03580980
- Locations
- 🇪🇬
Department of Anesthesia and Pain medicine.National Cancer Institute, Cairo, Egypt
Levorphanol as a Second Line Opioid in Reducing Pain in Patients With Cancer
- First Posted Date
- 2018-07-06
- Last Posted Date
- 2024-06-18
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 43
- Registration Number
- NCT03579446
- Locations
- 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States
TQL-block for Laparoscopic Hemicolectomy
- First Posted Date
- 2018-06-27
- Last Posted Date
- 2021-01-15
- Lead Sponsor
- Zealand University Hospital
- Target Recruit Count
- 69
- Registration Number
- NCT03570541
- Locations
- 🇩🇰
Zealand University Hospital, Department of Anaesthesiology, Roskilde, Denmark
Epidural Methadone in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2018-05-15
- Last Posted Date
- 2019-09-18
- Lead Sponsor
- simon.haroutounian
- Target Recruit Count
- 13
- Registration Number
- NCT03525509
- Locations
- 🇺🇸
Washington University in St. Louis, Saint Louis, Missouri, United States
Peri-Incisional Drug Injection in Lumbar Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-05-01
- Last Posted Date
- 2022-08-19
- Lead Sponsor
- University of Minnesota
- Registration Number
- NCT03513445
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Comparison of Treatment by IN Ketamine to IV Morphine in Acute Pain
- First Posted Date
- 2018-04-30
- Last Posted Date
- 2019-06-25
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT03511833
- Locations
- 🇮🇱
Tel Aviv Sourasky Medical Center, department of Emergency Medicine, Tel Aviv, Israel
Effect of Granisetron on Morphine Induced Pruritus in Cesarean Section
- First Posted Date
- 2018-03-30
- Last Posted Date
- 2021-09-09
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT03483870
- Locations
- 🇪🇬
Assiut University Hospital, Assiut, Egypt
Long Thoracic Nerve Blockade for Pain Treatment After Video-Assisted Thoracoscopic Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-03-30
- Last Posted Date
- 2018-03-30
- Target Recruit Count
- 60
- Registration Number
- NCT03483415
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.