Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Study of Buprenorphine Sublingual Spray Versus Standard of Care Narcotic Therapy for the Treatment of Post-Operative Pain
- Conditions
- Interventions
- First Posted Date
- 2017-08-18
- Last Posted Date
- 2018-10-29
- Lead Sponsor
- INSYS Therapeutics Inc
- Target Recruit Count
- 100
- Registration Number
- NCT03254459
- Locations
- 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States
🇺🇸Epic Medical Research, Murray, Utah, United States
Effect of Combined Morphine and Duloxetine on Chronic Pain
- Conditions
- Interventions
- First Posted Date
- 2017-08-15
- Last Posted Date
- 2024-11-14
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 81
- Registration Number
- NCT03249558
- Locations
- 🇺🇸
Karina de Sousa, Boston, Massachusetts, United States
Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia
- First Posted Date
- 2017-08-02
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- Nantes University Hospital
- Target Recruit Count
- 285
- Registration Number
- NCT03236805
- Locations
- 🇫🇷
Grenoble University Hospital, Grenoble, France
🇫🇷Tours University Hospital, Tours, France
🇫🇷La Roche sur Yon Hospital, La Roche sur Yon, France
Intrathecal Morphine for Unilateral Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2017-07-28
- Last Posted Date
- 2021-05-24
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 131
- Registration Number
- NCT03232957
- Locations
- 🇹🇭
Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok, Thailand
a Small Dose of Naloxone,Minimize Intrathecal Morphine Side Effects
- Conditions
- Interventions
- First Posted Date
- 2017-07-26
- Last Posted Date
- 2017-10-04
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 100
- Registration Number
- NCT03230474
- Locations
- 🇪🇬
Emad Zarief Kamel Said, Assiut, Egypt
Intranasal Sufentanil Versus Intravenous Morphine for the Management of Acute Pain
- First Posted Date
- 2017-07-21
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- The Brooklyn Hospital Center
- Target Recruit Count
- 40
- Registration Number
- NCT03224039
- Locations
- 🇺🇸
The Brooklyn Hospital Center, Brooklyn, New York, United States
Prevention of Hyperalgesia With Epidural Morphine
- First Posted Date
- 2017-07-21
- Last Posted Date
- 2018-03-05
- Lead Sponsor
- Cukurova University
- Target Recruit Count
- 105
- Registration Number
- NCT03225690
- Locations
- 🇹🇷
Çukurova University Balcalı Hospital, Adana, Turkey
Visual Pain Score and Perfusion Index in Postoperative Patients
- First Posted Date
- 2017-05-12
- Last Posted Date
- 2018-02-20
- Lead Sponsor
- Tokat Gaziosmanpasa University
- Target Recruit Count
- 89
- Registration Number
- NCT03151369
- Locations
- 🇹🇷
Gaziosmanpasa University, Tokat, Turkey
Methadone Demonstration Project With Neonatal Intensive Care Unit Infants Diagnosed With Neonatal Abstinence Syndrome
- First Posted Date
- 2017-05-01
- Last Posted Date
- 2023-07-03
- Lead Sponsor
- Johns Hopkins All Children's Hospital
- Target Recruit Count
- 11
- Registration Number
- NCT03134703
- Locations
- 🇺🇸
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States
Morphine in Moderate Obstructive Sleep Apnoea
- First Posted Date
- 2017-04-25
- Last Posted Date
- 2018-11-29
- Lead Sponsor
- Papworth Hospital NHS Foundation Trust
- Target Recruit Count
- 6
- Registration Number
- NCT03127800
- Locations
- 🇬🇧
Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridgeshire, United Kingdom
Drug Development Updates
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