Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

PECS-2 for Breast Surgery

Not Applicable

Completed

Conditions: Breast Neoplasm Female
Regional Anesthesia
Anesthesia
Regional Anesthesia Morbidity
Anesthesia Morbidity

Interventions: Drug: Ropivacaine 5 mg/ml, 35 ml
Drug: Remifentanil 50 microg/ml
Drug: Betamethason 4 mg
Drug: Paracetamol 1,5 g
Drug: Propofol
Drug: Arcoxia, 120 mg
Drug: Ondansetron 4 mg
Drug: Morphine

First Posted Date: 2017-04-18

Last Posted Date: 2021-06-04

Lead Sponsor: Umeå University

Target Recruit Count: 200

Registration Number: NCT03117894

Locations: 🇸🇪
Östersund Hospital, Östersund, Jämtland, Sweden

Robot-assisted Lobectomy Versus Video-assisted Lobectomy

Completed

Conditions: Anesthesia and Analgesia
Robotic Surgical Procedures
Cardiac Output
Pneumonectomy; Status

Interventions: Drug: Morphine
Other: Cardiac output measure

First Posted Date: 2017-04-13

Last Posted Date: 2020-04-22

Lead Sponsor: Hospital Nord

Target Recruit Count: 200

Registration Number: NCT03111797

Locations: 🇫🇷
Departement anesthesie reanimation hopital nord, Marseille, France

Dose Escalation of Dexamethasone to Increase Duration of Transversus Abdominal Plane Block Following Cesarean Section

Phase 2

Terminated

Conditions: Post Surgical Pain

Interventions: Drug: Ropivacaine (TAP blocks)
Drug: 2mg Dexamethasone
Drug: 4mg Dexamethasone
Drug: Morphine
Drug: Bupivacaine Hydrochloride
Drug: Normal saline 1ml
Drug: Normal saline 0.5ml

First Posted Date: 2017-03-31

Last Posted Date: 2021-06-18

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 29

Registration Number: NCT03098420

Locations: 🇺🇸
UAB Department of Anesthesiology and Perioperative Medicine, Birmingham, Alabama, United States

Treatment of Neonatal Abstinence Syndrome With Clonidine Versus Morphine as Primary Therapy

Phase 4

Active, not recruiting

Conditions: Neonatal Abstinence Syndrome

Interventions: Drug: Clonidine
Drug: Morphine Sulfate

First Posted Date: 2017-03-27

Last Posted Date: 2024-10-11

Lead Sponsor: The Cooper Health System

Target Recruit Count: 69

Registration Number: NCT03092011

Locations: 🇺🇸
Cooper University Hospital, Camden, New Jersey, United States

Analgesic Efficacy of (MSIR)/Acetaminophen vs. Oxycodone/Acetaminophen (Percocet)

Phase 2

Completed

Conditions: Pain Management

Interventions: Drug: Morphine Sulfate
Drug: Oxycodone
Drug: Acetaminophen

First Posted Date: 2017-03-23

Last Posted Date: 2022-03-14

Lead Sponsor: Antonios Likourezos

Target Recruit Count: 80

Registration Number: NCT03088826

Locations: 🇺🇸
Maimonides Medical Center, Brooklyn, New York, United States

Ultrasound-guided Transmuscular Quadratus Lumborum Block for Elective Caesarean Section.

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine
Drug: Saline
Drug: Acetaminophen
Drug: Ibuprofen 400Mg Tablet / Celebra 100 Mg tablet
Device: ultrasound-guided nerve block
Drug: Morphine
Device: Patient-controlled analgesia

First Posted Date: 2017-03-01

Last Posted Date: 2018-03-23

Lead Sponsor: Zealand University Hospital

Target Recruit Count: 72

Registration Number: NCT03068260

Locations: 🇩🇰
ZUH, Roskilde, Danmark, Denmark

QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE

Phase 4

Completed

Conditions: Nausea and Vomiting, Postoperative
Pain, Postoperative

Interventions: Drug: Morphine
Drug: Methadone

First Posted Date: 2017-02-07

Last Posted Date: 2017-05-08

Lead Sponsor: Pontificia Universidade Catolica de Sao Paulo

Target Recruit Count: 70

Registration Number: NCT03045133

Locations: 🇧🇷
Santa Lucinda Hospital, Sorocaba, SP, Brazil

Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair

Not Applicable

Conditions: Hernia, Inguinal
Pain, Postoperative

Interventions: Procedure: Caudal-epidural nerve block
Procedure: Ilioinguinal/iliohypogastric nerve block
Drug: Acetaminophen
Drug: Sevoflurane
Drug: Remifentanil
Drug: Propofol
Drug: Morphine
Drug: Ondansetron
Drug: Dexamethasone
Drug: Ketorolac

First Posted Date: 2017-02-03

Last Posted Date: 2017-11-14

Lead Sponsor: Alberta Children's Hospital

Target Recruit Count: 88

Registration Number: NCT03041948

Locations: 🇨🇦
Alberta Children's Hospital, Calgary, Alberta, Canada
🇨🇦
Royal University Hospital/University of Saskatchewan, Saskatoon, Saskatchewan, Canada