Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

Not Applicable

Completed

Conditions: Obstetric Surgical Procedures
Analgesia, Obstetrical

Interventions: Drug: Hydromorphone
Drug: Morphine

First Posted Date: 2016-06-03

Last Posted Date: 2019-04-25

Lead Sponsor: Mayo Clinic

Target Recruit Count: 134

Registration Number: NCT02789410

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Comparison of Surgical Rectus Sheath Block and Intrathecal Morphine

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Bupivacaine
Drug: Morphine

First Posted Date: 2016-06-03

Last Posted Date: 2016-10-04

Lead Sponsor: Queen Mary Hospital, Hong Kong

Target Recruit Count: 144

Registration Number: NCT02790099

Locations: 🇭🇰
Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, Hong Kong

Morphine Versus Ketorolac in Low Back Pain

Phase 4

Conditions: Low Back Pain

Interventions: Drug: Morphine
Drug: Ketorolac

First Posted Date: 2016-05-25

Last Posted Date: 2016-05-25

Lead Sponsor: Loredana Ghinea

Target Recruit Count: 100

Registration Number: NCT02782286

Morphine Versus Ketorolac in Renal Colic

Phase 4

Conditions: Renal Colic

Interventions: Drug: Morphine
Drug: Ketorolac

First Posted Date: 2016-05-25

Last Posted Date: 2016-05-25

Lead Sponsor: Loredana Ghinea

Target Recruit Count: 100

Registration Number: NCT02782273

Electroacupuncture for Laparoscopic/ Robotic Colorectal Surgery

Not Applicable

Terminated

Conditions: Acute Pain

Interventions: Device: electroacupuncture
Drug: morphine

First Posted Date: 2016-05-16

Last Posted Date: 2020-03-26

Lead Sponsor: The University of Hong Kong

Target Recruit Count: 70

Registration Number: NCT02773472

Locations: 🇭🇰
The University of Hong Kong, Hong Kong, Hong Kong

Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture

Phase 3

Terminated

Conditions: Parecoxib
Rib Fractures

Interventions: Drug: Parecoxib
Drug: Morphine

First Posted Date: 2016-04-25

Last Posted Date: 2020-01-31

Lead Sponsor: Chang Gung Memorial Hospital

Target Recruit Count: 17

Registration Number: NCT02749409

Perineural Dexamethasone in Femural Nerve Block After Ligament Reconstruction

Phase 3

Completed

Conditions: Postoperative Pain

Interventions: Drug: Dexamethasone phosphate
Drug: Paracetamol
Drug: Morphine
Drug: Lidocaine
Drug: Ropivacaine

First Posted Date: 2016-04-22

Last Posted Date: 2017-08-02

Lead Sponsor: Foisor Orthopedics Clinical Hospital

Target Recruit Count: 90

Registration Number: NCT02749162

Locations: 🇷🇴
Foisor Orthopedics Clinical Hospital, Bucharest, Romania

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

Phase 4

Terminated

Conditions: Acute Pain, Postoperative

Interventions: Drug: IV acetaminophen
Drug: Oral acetaminophen
Drug: Morphine

First Posted Date: 2016-04-21

Last Posted Date: 2019-11-19

Lead Sponsor: Mallinckrodt

Target Recruit Count: 1

Registration Number: NCT02746263

Locations: 🇺🇸
Pensacola Research Consultants, Pensacola, Florida, United States
🇺🇸
The Ohio State University, Wexner Medical Center, Columbus, Ohio, United States

Multimodal Analgesia in Cardiac Surgery (Pilot Study)

Phase 4

Terminated

Conditions: Heart Diseases

Interventions: Drug: Unrestricted Fentanyl
Drug: Lidocaine
Drug: Ketamine
Drug: Precedex
Drug: Duramorph

First Posted Date: 2016-04-12

Last Posted Date: 2018-08-07

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 3

Registration Number: NCT02734940

Locations: 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Breathlessness Exertion and Morphine Sulphate

Phase 3

Completed

Conditions: Chronic Obstructive Pulmonary Disease
Dyspnea

Interventions: Drug: Placebo
Drug: Plus placebo laxative
Drug: Plus laxative (Docusate with senna)
Drug: Morphine Sulfate
Device: FitBit charge HR (Accelerometer)

First Posted Date: 2016-03-28

Last Posted Date: 2020-02-11

Lead Sponsor: Flinders University

Target Recruit Count: 171

Registration Number: NCT02720822

Locations: 🇦🇺
Clare Holland House, Canberra, Australian Capital Territory, Australia
🇦🇺
Barwon Health McKellar Centre, Geelong, Victoria, Australia
🇦🇺
Royal Melbourne Hospital, Melbourne, Victoria, Australia

and more 12 locations

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