Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome

Phase 4

Completed

Conditions: Neonatal Abstinence Syndrome

Interventions: Drug: Morphine
Drug: Methadone

First Posted Date: 2016-08-01

Last Posted Date: 2023-05-24

Lead Sponsor: University of New Mexico

Target Recruit Count: 61

Registration Number: NCT02851303

Locations: 🇺🇸
University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States

The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery

Phase 2

Completed

Conditions: Postoperative Cognitive Dysfunction

Interventions: Drug: morphine
Drug: levobupivacaine

First Posted Date: 2016-07-28

Last Posted Date: 2020-09-01

Lead Sponsor: Osijek University Hospital

Target Recruit Count: 86

Registration Number: NCT02848599

Locations: 🇭🇷
Clinical Hospital Centre Osijek, Osijek, Croatia

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty

Phase 3

Completed

Conditions: Acute Pain

Interventions: Drug: Placebo
Drug: Oliceridine
Drug: Morphine

First Posted Date: 2016-06-30

Last Posted Date: 2020-10-23

Lead Sponsor: Trevena Inc.

Target Recruit Count: 407

Registration Number: NCT02820324

Locations: 🇺🇸
Research Site, San Antonio, Texas, United States

Intranasal Ketamine for Acute Traumatic Pain

Phase 4

Completed

Conditions: Acute Pain

Interventions: Drug: Morphine
Drug: Ketamine Hydrochloride

First Posted Date: 2016-06-29

Last Posted Date: 2016-06-30

Lead Sponsor: Tel Aviv Medical Center

Target Recruit Count: 90

Registration Number: NCT02817477

Locations: 🇮🇱
Tel Aviv Medical Center, Tel Aviv, Israel

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy

Phase 3

Completed

Conditions: Acute Pain

Interventions: Drug: Oliceridine
Drug: Placebo
Drug: Morphine

First Posted Date: 2016-06-28

Last Posted Date: 2020-09-25

Lead Sponsor: Trevena Inc.

Target Recruit Count: 418

Registration Number: NCT02815709

Locations: 🇺🇸
Research Site, San Antonio, Texas, United States
🇺🇸
Resarch Site, Salt Lake City, Utah, United States

How to Treat Opiate Withdrawal in Neonates

Phase 3

Completed

Conditions: Neonatal Abstinence Syndrome

Interventions: Drug: Chlorpromazine
Drug: Phenobarbital
Drug: Morphine

First Posted Date: 2016-06-23

Last Posted Date: 2020-01-07

Lead Sponsor: University of Zurich

Target Recruit Count: 120

Registration Number: NCT02810782

Vital-signs-integrated Patient-assisted Intravenous Opioid Analgesia

Phase 2

Active, not recruiting

Conditions: Respiratory Depression

Interventions: Device: VPIA analgesia
Drug: Morphine

First Posted Date: 2016-06-17

Last Posted Date: 2024-10-09

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 20

Registration Number: NCT02804022

Locations: 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

Comparison of Two Pain-treatment Techniques After Cesarean Section

Phase 4

Completed

Conditions: Cesarean Section
Neuropathic Pain
Pain Management

Interventions: Procedure: TAP (transversus abdominis plane block)
Procedure: QL (quadratus lumborum block)
Drug: Bupivacaine
Device: Needle
Drug: Paracetamol
Drug: Metamizol
Drug: Ketoprofen
Drug: Morphine

First Posted Date: 2016-06-17

Last Posted Date: 2023-11-28

Lead Sponsor: Michał Borys

Target Recruit Count: 232

Registration Number: NCT02804126

Locations: 🇵🇱
II Department of Anesthesia and Intensive Care, Lublin, Poland

Validation of an Observational Scale of Dyspnea in Non-communicating Patients in the ICU

Not Applicable

Completed

Conditions: Dyspnea

Interventions: Drug: Morphine

First Posted Date: 2016-06-16

Last Posted Date: 2017-08-01

Lead Sponsor: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Target Recruit Count: 50

Registration Number: NCT02801838

Locations: 🇫🇷
Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière Paris, France, Paris, France

Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures

Phase 4

Completed

Conditions: Pain, Postoperative
Femur Fracture

Interventions: Drug: Ropivacaine
Drug: Epinephrine
Drug: Morphine
Drug: 0.9% sodium chloride solution

First Posted Date: 2016-06-08

Last Posted Date: 2018-04-05

Lead Sponsor: University of Iowa

Target Recruit Count: 102

Registration Number: NCT02793947

Locations: 🇺🇸
University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

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