Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorp...
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Evaluation of the Interactions of Cannabidiol (CBD) With Morphine
- First Posted Date
- 2021-12-03
- Last Posted Date
- 2024-03-27
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Target Recruit Count
- 60
- Registration Number
- NCT05143424
- Locations
- 🇺🇸
AltaSciences, Overland Park, Kansas, United States
Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.
- Conditions
- Interventions
- First Posted Date
- 2021-11-11
- Last Posted Date
- 2024-11-20
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 115
- Registration Number
- NCT05117034
- Locations
- 🇮🇱
Tel-Aviv Medical Center, Sackler faculty of medicine, Tel-Aviv University, Israel, Tel Aviv, Israel
Nalbuphine Versus Morphine for Perioperative Tumor Ablation
- Conditions
- Interventions
- First Posted Date
- 2021-10-11
- Last Posted Date
- 2022-12-29
- Lead Sponsor
- Zhongda Hospital
- Target Recruit Count
- 316
- Registration Number
- NCT05073744
- Locations
- 🇨🇳
The Second Hospital of Anhui Medical University, Hefei, Anhui, China
🇨🇳The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
🇨🇳Anhui Province Cancer Hospital, Hefei, Anhui, China
Intrathecal Morphine for Cesarean Delivery
- First Posted Date
- 2021-10-06
- Last Posted Date
- 2024-05-07
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 72
- Registration Number
- NCT05069012
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain
- Conditions
- Interventions
- First Posted Date
- 2021-09-08
- Last Posted Date
- 2022-08-31
- Lead Sponsor
- Rajavithi Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT05037539
- Locations
- 🇹🇭
Rajavithi Hospital, Bangkok, Thailand
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
- Conditions
- Interventions
- First Posted Date
- 2021-08-31
- Last Posted Date
- 2024-02-29
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 60
- Registration Number
- NCT05027919
- Locations
- 🇺🇸
Johns Hopkins University Bayview Medical Campus, Baltimore, Maryland, United States
Comparison Between Pericapsular Nerve Group Block (PENG) and Morphine Infusion
- Conditions
- Interventions
- First Posted Date
- 2021-08-26
- Last Posted Date
- 2022-09-13
- Lead Sponsor
- Suez Canal University
- Target Recruit Count
- 36
- Registration Number
- NCT05023473
- Locations
- 🇪🇬
Suez Canal University, Ismailia, Egypt
Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy
- Conditions
- Interventions
- First Posted Date
- 2021-08-23
- Last Posted Date
- 2024-05-23
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 174
- Registration Number
- NCT05017246
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Opioid/Benzodiazepine Polydrug Abuse: Aim 3
- Conditions
- Interventions
- First Posted Date
- 2021-08-16
- Last Posted Date
- 2024-08-29
- Lead Sponsor
- Wayne State University
- Target Recruit Count
- 24
- Registration Number
- NCT05006079
- Locations
- 🇺🇸
Tolan Park Medical Building, Detroit, Michigan, United States
Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2021-05-26
- Last Posted Date
- 2021-06-18
- Lead Sponsor
- Copenhagen University Hospital, Hvidovre
- Target Recruit Count
- 26
- Registration Number
- NCT04902222
- Locations
- 🇩🇰
Hvidovre University Hospital, Hvidovre, Denmark
Drug Development Updates
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