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Morphine

Generic Name
Morphine
Brand Names
Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
Drug Type
Small Molecule
Chemical Formula
C17H19NO3
CAS Number
57-27-2
Unique Ingredient Identifier
76I7G6D29C
Background

Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication

Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions
Chronic Pain, Severe Pain
Associated Therapies
-

Split Scripts for Pediatric Supracondylar Fracture Repairs

Not Applicable
Completed
Conditions
Pain, Postoperative
Interventions
First Posted Date
2022-05-12
Last Posted Date
2023-11-21
Lead Sponsor
The Hospital for Sick Children
Target Recruit Count
175
Registration Number
NCT05372133
Locations
🇨🇦

The Hospital for Sick Children, Toronto, Ontario, Canada

Platelet Reactivity with Fentanyl, Morphine, or No Narcotic

Early Phase 1
Recruiting
Conditions
Platelet Reactivity
Fentanyl
Interventions
First Posted Date
2022-05-10
Last Posted Date
2024-11-28
Lead Sponsor
Spectrum Health - Lakeland
Target Recruit Count
100
Registration Number
NCT05367336
Locations
🇺🇸

Spectrum Health Lakeland, Saint Joseph, Michigan, United States

Pain Multidisciplinar Intervention in Major Trauma Patients

Recruiting
Conditions
Trauma
Chronic Pain
Psychological Trauma
Interventions
First Posted Date
2022-05-02
Last Posted Date
2024-08-20
Lead Sponsor
Nuria Llorach-Perucho
Target Recruit Count
80
Registration Number
NCT05355441
Locations
🇪🇸

Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain

Intrathecal Morphine for Analgesia in Video-assisted Thoracic Surgery

Phase 4
Recruiting
Conditions
Pain, Postoperative
Interventions
First Posted Date
2022-04-28
Last Posted Date
2025-01-09
Lead Sponsor
University of Chicago
Target Recruit Count
90
Registration Number
NCT05351229
Locations
🇺🇸

University of Chicago, Chicago, Illinois, United States

Ultrasound-Guided TAP Block and Spinal Morphine for Pain Relief After Caesarean Section

Not Applicable
Completed
Conditions
Post Operative Pain
Interventions
Procedure: Ultrasound-Guided Transversus Abdominis Plane Block
Drug: Morphine
First Posted Date
2022-04-18
Last Posted Date
2022-04-18
Lead Sponsor
Sohag University
Target Recruit Count
60
Registration Number
NCT05331781
Locations
🇪🇬

Faculty of Medicine, Sohag University, Sohag, Egypt

Methadone for 'Adenocarcinopathic' Pain Treatment

Phase 3
Withdrawn
Conditions
Cancer Pain
Adenocarcinoma
Interventions
First Posted Date
2022-04-13
Last Posted Date
2022-12-05
Lead Sponsor
Ottawa Hospital Research Institute
Registration Number
NCT05325164

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Phase 3
Recruiting
Conditions
Pain, Postoperative
Interventions
Drug: Morphine Sulfate
Other: Intravenous Placebo for NTM-001
Drug: Ketorolac Tromethamine
Other: IV Placebo for Morphine
First Posted Date
2022-04-12
Last Posted Date
2024-03-21
Lead Sponsor
NEMA Research, Inc.
Target Recruit Count
360
Registration Number
NCT05324358
Locations
🇺🇸

The Orthopedic Center, Tulsa, Oklahoma, United States

🇺🇸

Sun City Clinical Research, Sun City, Arizona, United States

🇺🇸

Trovare Clinical Research, Bakersfield, California, United States

and more 7 locations

Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy

Phase 1
Withdrawn
Conditions
Opioid Use Disorder, Moderate
Interventions
Drug: Levomethadone HCl
Drug: Methadone
Drug: Morphine Sulfate
Diagnostic Test: x-ray
Diagnostic Test: blood tests
First Posted Date
2022-02-22
Last Posted Date
2023-01-19
Lead Sponsor
Lyndra Inc.
Registration Number
NCT05251376

Subcutaneous Versus Intravenous Morphine When Switching From Oral to Parenteral Route in Palliative Cancer Patients

Phase 3
Recruiting
Conditions
Pain Cancer
Interventions
First Posted Date
2022-02-11
Last Posted Date
2023-12-26
Lead Sponsor
University Hospital, Akershus
Target Recruit Count
60
Registration Number
NCT05236647
Locations
🇳🇴

Akershus University Hospital, Lørenskog, Norway

Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection

Not Applicable
Completed
Conditions
Patients Receiving Hepatectomy Under General Anesthesia
Interventions
Drug: Percutaneous injection
Drug: Morphine+Bupivacaine
Drug: Morphine
First Posted Date
2022-01-26
Last Posted Date
2022-01-26
Lead Sponsor
Yonsei University
Target Recruit Count
90
Registration Number
NCT05208801
Locations
🇰🇷

Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of

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