Ibuprofen

Generic Name: Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₈O_₂

CAS Number: 15687-27-1

Unique Ingredient Identifier: WK2XYI10QM

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Associated Therapies: -

Clinical Trials

NSAID Use After Robotic Partial Nephrectomy

Phase 2

Recruiting

Conditions: Renal Neoplasm
Renal Cancer
Kidney Cancer

Interventions: Drug: Ketorolac
Drug: Acetaminophen
Drug: Oxycodone
Drug: Hydromorphone
Drug: Ibuprofen

First Posted Date: 2023-05-03

Last Posted Date: 2024-10-08

Lead Sponsor: University of Miami

Target Recruit Count: 110

Registration Number: NCT05842044

Locations: 🇺🇸
University of Miami, Miami, Florida, United States

Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy

Phase 2

Active, not recruiting

Conditions: Post Operative Analgesia

Interventions: Drug: Ibuprofen

First Posted Date: 2023-03-01

Last Posted Date: 2024-01-26

Lead Sponsor: Menoufia University

Target Recruit Count: 152

Registration Number: NCT05750264

Locations: 🇪🇬
Faculty of Medicine, Cairo, Shebin Elkom, Egypt

Post-operative Pain Management in Children With Supracondylar Humerus Fractures

Phase 4

Conditions: Supracondylar Humerus Fracture

Interventions: Drug: Ibuprofen
Drug: Hydrocodone/acetaminophen
Drug: Acetaminophen

First Posted Date: 2022-12-07

Last Posted Date: 2023-09-13

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 100

Registration Number: NCT05640674

Locations: 🇺🇸
Texas Children's Hospital - West Campus, Houston, Texas, United States
🇺🇸
Texas Children's Hospital - Woodlands Campus, Houston, Texas, United States
🇺🇸
Texas Children's Hospital - Main Campus, Houston, Texas, United States

Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Thyroidectomy

Not Applicable

Recruiting

Conditions: Thyroid Disease

Interventions: Drug: Acetaminophen
Drug: Ibuprofen

First Posted Date: 2022-11-23

Last Posted Date: 2022-11-25

Lead Sponsor: The Catholic University of Korea

Target Recruit Count: 62

Registration Number: NCT05626010

Locations: 🇰🇷
Seoul St. Mary's Hospital, Seoul, Seocho-gu, Korea, Republic of

Effectiveness of Pre-emptive Analgesics on Post-Operative Pain After Stainless Steel Crown Placement On Primary Molars

Phase 4

Completed

Conditions: Post-operative Pain

Interventions: Other: Placebo
Drug: Ibuprofen
Drug: Paracetamol

First Posted Date: 2022-11-01

Last Posted Date: 2023-02-23

Lead Sponsor: Alexandria University

Target Recruit Count: 66

Registration Number: NCT05602064

Locations: 🇪🇬
Pediatric Dentistry department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Safety of Ibuprofen After Major Orthopaedic Surgeries

Phase 4

Recruiting

Conditions: Knee Arthropathy
Analgesia
Analgesic Adverse Reaction
Postoperative Pain
Pain, Acute
Hip Arthropathy
Postoperative Complications
Safety Issues