Somatostatin

Generic Name: Somatostatin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₇₆H_₁₀₄N_₁₈O_₁₉S_₂

CAS Number: 38916-34-6

Unique Ingredient Identifier: 6E20216Q0L

Background: Somatostatin, also known as growth hormone-inhibiting hormone, is a naturally-occurring peptide hormone of 14 or 28 amino acid residues that regulates the endocrine system. It is secreted by the D cells of the islets to inhibit the release of insulin and glucagon, and is also generated in the hypothalamus, where it inhibits the release of growth hormone and...

Indication: For the symptomatic treatment of acute bleeding from esophageal varices. Other treatment options for long-term management of the condition may be considered if necessary, once initial control has been established.

Associated Conditions: Acromegaly, Bleeding caused by Gastritis erosive, Diabetic Ketoacidosis, Duodenal ulcer haemorrhage, Fistula of small intestine, Fistula, Biliary, Gastric ulcer haemorrhage, Gastritis haemorrhagic, Oesophageal varices haemorrhage, Pancreatic Fistula, Postoperative Complications caused by Pancreatic Surgery

Associated Therapies: Restriction of Secretions

Clinical Trials

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

Early Phase 1

Recruiting

Conditions: Obesity

Interventions: Drug: Somatostatin
Drug: Epinephrine

First Posted Date: 2024-05-16

Last Posted Date: 2024-12-05

Lead Sponsor: Mayo Clinic

Target Recruit Count: 24

Registration Number: NCT06416969

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding

Phase 4

Completed

Conditions: Cirrhosis, Liver
Upper Gastrointestinal Bleeding

Interventions: Drug: Terlipressin
Drug: Somatostatin

First Posted Date: 2020-04-22

Last Posted Date: 2020-04-22

Lead Sponsor: Changhai Hospital

Target Recruit Count: 54

Registration Number: NCT04358016

Locations: 🇨🇳
Changhai hospital, Shanghai, China

Somatostatin in Living Donor Liver Transplantation

Phase 4

Conditions: End Stage Liver DIsease
Portal Hypertension

Interventions: Drug: Somatostatin
Drug: Placebo

First Posted Date: 2019-09-27

Last Posted Date: 2019-09-27

Lead Sponsor: King Faisal Specialist Hospital & Research Center

Target Recruit Count: 56

Registration Number: NCT04107428

The Role of Somatostatin in the Hemodynamics of the Hepatic Circulation in Patients Undergoing Liver Resection

Phase 3

Conditions: Portal Hypertension

Interventions: Drug: Somatostatin
Drug: Placebo

First Posted Date: 2019-07-08

Last Posted Date: 2019-07-08

Lead Sponsor: Laikο General Hospital, Athens

Target Recruit Count: 40

Registration Number: NCT04010669

Direct Measurement of Proinsulin Clearance in Humans

Phase 4

Withdrawn

Conditions: Healthy

Interventions: Drug: Somatostatin

First Posted Date: 2019-06-26

Last Posted Date: 2022-12-15

Lead Sponsor: Mayo Clinic

Registration Number: NCT03998293

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion

Phase 4

Withdrawn

Conditions: Healthy

Interventions: Drug: Somatostatin
Other: Dextrose
Drug: Insulin
Other: Intralipid

First Posted Date: 2019-06-26

Last Posted Date: 2022-09-09

Lead Sponsor: Mayo Clinic

Registration Number: NCT03998709

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage

Completed

Conditions: Variceal Hemorrhage
Kidney Injury
Cirrhosis, Liver

Interventions: Drug: Somatostatin
Drug: Terlipressin
Drug: Octreotide

First Posted Date: 2019-02-19

Last Posted Date: 2019-07-05

Lead Sponsor: General Hospital of Shenyang Military Region

Target Recruit Count: 1682

Registration Number: NCT03846180

Locations: 🇨🇳
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
🇨🇳
Department of Gastroenterology, Air Force Hospital of Northern Theater Command, Shenyang, Liaoning, China
🇨🇳
Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China

and more 11 locations

Somatostatin Prevent Post-operation Pancreatic Fistula in Intermediate Risk Patients After Pancreaticoduodenectomy

Phase 4

Completed

Conditions: Pancreatic Fistula

Interventions: Drug: Somatostatin

First Posted Date: 2017-11-21

Last Posted Date: 2020-02-13

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 205

Registration Number: NCT03349424

Locations: 🇨🇳
Peking Union Medical College Hospital, Beijing, Beijing, China

Liver Glycogen and Hypoglycemia in Humans

Phase 1

Active, not recruiting

Conditions: Hypoglycemia; Iatrogenic

Interventions: Drug: Saline
Drug: Low Fructose
Drug: Somatostatin
Drug: Insulin
Drug: Glucagon
Drug: High Fructose
Drug: Dextrose solution

First Posted Date: 2017-08-07

Last Posted Date: 2024-02-28

Lead Sponsor: Jason Winnick

Target Recruit Count: 40

Registration Number: NCT03241706

Locations: 🇺🇸
University of Cincinnati, Cincinnati, Ohio, United States

Prevention of Postoperative Pancreatic Fistula by Somatostatin

Phase 3

Completed

Conditions: Pancreatic Surgery

Interventions: Drug: Somatostatin
Drug: Octreotide

First Posted Date: 2016-12-22

Last Posted Date: 2021-05-03

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 655

Registration Number: NCT03000946

Locations: 🇫🇷
Cochin Hospital, Paris, France
🇫🇷
La Pitié Salpêtrière Hospital, Paris, France

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