Nitrofurantoin
- Generic Name
- Nitrofurantoin
- Brand Names
- Furadantin, Macrobid, Macrodantin
- Drug Type
- Small Molecule
- Chemical Formula
- C8H6N4O5
- CAS Number
- 67-20-9
- Unique Ingredient Identifier
- 927AH8112L
- Background
Nitrofurantoin is a nitrofuran antibiotic used to treat uncomplicated urinary tract infections. Nitrofurantoin is converted by bacterial nitroreductases to electrophilic intermediates which inhibit the citric acid cycle as well as synthesis of DNA, RNA, and protein. This drug is more resistant to the development of bacterial resistance because it acts on man...
- Indication
Nitrofurantoin is indicated to treat acute uncomplicated urinary tract infections.
- Associated Conditions
- Acute Cystitis, Urinary Tract Infection
- Associated Therapies
- -
Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis
- Conditions
- Interventions
- First Posted Date
- 2024-11-29
- Last Posted Date
- 2024-12-16
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 248
- Registration Number
- NCT06709196
- Locations
- 🇩🇰
Department of Urology, Aalborg University Hospital, Aalborg, Denmark
🇩🇰Department of Urology, Aarhus University Hospital, Aarhus, Denmark
🇩🇰Department of Urology, Rigshospitalet, Copenhagen, Denmark
Intravesical Gentamicin to Prevent Recurrent UTI
- First Posted Date
- 2024-03-27
- Last Posted Date
- 2024-03-28
- Lead Sponsor
- Women and Infants Hospital of Rhode Island
- Target Recruit Count
- 30
- Registration Number
- NCT06332781
Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study
- Conditions
- Interventions
- First Posted Date
- 2022-12-15
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Radboud University Medical Center
- Target Recruit Count
- 100
- Registration Number
- NCT05652374
- Locations
- 🇳🇱
Rijnstate ziekenhuis, Arnhem, Netherlands
🇳🇱Canisius wilhelmina ziekenhuis, Nijmegen, Netherlands
🇳🇱Radboudumc, Nijmegen, Gelderland, Netherlands
A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis)
- Conditions
- Interventions
- First Posted Date
- 2022-11-30
- Last Posted Date
- 2024-08-28
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 382
- Registration Number
- NCT05630833
- Locations
- 🇯🇵
GSK Investigational Site, Tokyo, Japan
The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste
- Conditions
- Interventions
- First Posted Date
- 2022-10-31
- Last Posted Date
- 2022-10-31
- Lead Sponsor
- Altamash Institute of Dental Medicine
- Target Recruit Count
- 60
- Registration Number
- NCT05600023
- Locations
- 🇵🇰
Hira Danish, Karachi, Sindh, Pakistan
Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA
- First Posted Date
- 2022-08-29
- Last Posted Date
- 2024-03-27
- Lead Sponsor
- Atlantic Health System
- Target Recruit Count
- 140
- Registration Number
- NCT05519072
- Locations
- 🇺🇸
Atlantic Health, Morristown, New Jersey, United States
Role of Prophylactic Postoperative Antibiotics in HoLEP
- First Posted Date
- 2022-03-10
- Last Posted Date
- 2022-03-11
- Lead Sponsor
- Baylor Research Institute
- Target Recruit Count
- 100
- Registration Number
- NCT05274672
- Locations
- 🇺🇸
Einstein Healthcare network, Philadelphia, Pennsylvania, United States
🇺🇸Baylor Scott and White, Temple, Texas, United States
EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary Care
- Conditions
- Interventions
- First Posted Date
- 2022-02-24
- Last Posted Date
- 2022-03-15
- Lead Sponsor
- MJM Bonten
- Target Recruit Count
- 13
- Registration Number
- NCT05254808
- Locations
- 🇳🇱
UMC Utrecht, Utrecht, Netherlands
🇳🇱Medisch Centrum Heuvelrug, Doorn, Utrecht, Netherlands
🇳🇱Huisartsenpraktijk Binnenstad, Utrecht, Netherlands
Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract Infections
- Conditions
- Interventions
- First Posted Date
- 2021-12-01
- Last Posted Date
- 2024-11-13
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 122
- Registration Number
- NCT05138822
- Locations
- 🇺🇸
GSK Investigational Site, Missouri City, Texas, United States
Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.
- Conditions
- Interventions
- First Posted Date
- 2021-07-13
- Last Posted Date
- 2023-12-11
- Target Recruit Count
- 1000
- Registration Number
- NCT04959331
- Locations
- 🇪🇸
Calatayud Center, Calatayud, Aragón, Spain
🇪🇸Parque Goya Health Center, Zaragoza, Aragón, Spain
🇪🇸Montblanc Center, Montblanc, Catalonia, Spain
Drug Development Updates
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