Epinephrine

Generic Name
Epinephrine
Brand Names
Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine, Eurneffy
Drug Type
Small Molecule
Chemical Formula
C9H13NO3
CAS Number
51-43-4
Unique Ingredient Identifier
YKH834O4BH
Background

Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new produ...

Indication

Epinephrine injection is indicated in the emergency treatment of type I allergic reactions, including anaphylaxis. It is also used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
...

Associated Conditions
Anaphylaxis, Angioneurotic Edema, Bleeding, Bronchospasm, Complete Heart Block, Hypotension, Idiopathic Anaphylaxis, Laryngotracheobronchitis, Mild Intermittent Asthma, Nasal Congestion, Open Angle Glaucoma (OAG), Respiratory Distress, Severe Asthma, Syncope, Type I Hypersensitivity, Urticaria, Uterine Contractions, Ventricular Fibrillation, Resuscitation in cardiac arrest following anesthetic accidents, Severe hypersensitivity reactions, Unresponsive Asystole, Unresponsive Bradycardia
Associated Therapies
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Femoral Nerve Block for Femur Fracture Repair in Pediatrics

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2013-01-03
Last Posted Date
2018-01-25
Lead Sponsor
Nationwide Children's Hospital
Target Recruit Count
19
Registration Number
NCT01759407
Locations
🇺🇸

Nationwide Children's, Columbus, Ohio, United States

The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

Phase 3
Completed
Conditions
Interventions
First Posted Date
2012-10-17
Last Posted Date
2015-02-18
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
106
Registration Number
NCT01708642
Locations
🇩🇰

Hvidovre Hospital, Department of orthopaedic surgery, Hvidovre, Denmark

🇩🇰

Vejle Sygehus, Department of orthopedic surgery, Vejle, Denmark

🇩🇰

Gentofte Hospital, Department of Anaesthesia, Hellerup, Denmark

Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery

Phase 4
Completed
Conditions
Interventions
First Posted Date
2012-10-15
Last Posted Date
2017-05-03
Lead Sponsor
Marc Tewfik
Target Recruit Count
45
Registration Number
NCT01706952
Locations
🇨🇦

Department of Otolaryngology-Head and Neck Surgery. McGill University Health Center, Montreal, Quebec, Canada

Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled Trial

First Posted Date
2012-04-23
Last Posted Date
2018-11-28
Lead Sponsor
University of Massachusetts, Worcester
Target Recruit Count
90
Registration Number
NCT01583166
Locations
🇺🇸

University of Massachusetts, Worcester, Massachusetts, United States

Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers

First Posted Date
2012-03-22
Last Posted Date
2013-09-25
Lead Sponsor
Zagazig University
Target Recruit Count
100
Registration Number
NCT01560702
Locations
🇪🇬

Zagazig University Hospitals, Zagazig, Sharkia, Egypt

A Study for Absorption of Intranasal Epinephrine Compared to Conventional Intramuscular Epinephrine

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2011-09-13
Last Posted Date
2011-09-13
Lead Sponsor
Siriraj Hospital
Target Recruit Count
12
Registration Number
NCT01432522
Locations
🇹🇭

Facaulty of Medicine, Siriraj Hospital, Bangkok, Thailand

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery

First Posted Date
2011-08-16
Last Posted Date
2011-08-16
Lead Sponsor
Oxford University Hospitals NHS Trust
Target Recruit Count
25
Registration Number
NCT01418118
Locations
🇬🇧

John Radcliffe Hospital, Oxford, Oxfordshire, United Kingdom

Study of Intracameral Adrenaline for Pupil Dilation Without Topical Mydriatics in Refractive Cataract Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2010-12-22
Last Posted Date
2012-07-06
Lead Sponsor
Wenzhou Medical University
Target Recruit Count
60
Registration Number
NCT01264653
Locations
🇨🇳

Wenzhou Medical College, Wenzhou, Zhejiang, China

Comparison of Perfusion Index, T Wave Amplitude, Systolic Blood Pressure and Heart Rate

Not Applicable
Conditions
Interventions
First Posted Date
2010-05-27
Last Posted Date
2011-02-15
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
50
Registration Number
NCT01131741
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Not Applicable
Completed
Conditions
First Posted Date
2010-05-05
Last Posted Date
2011-11-06
Lead Sponsor
University of Aarhus
Target Recruit Count
10
Registration Number
NCT01116609
Locations
🇩🇰

Medical research laboratories, Aarhus University Hospital, Aarhus, Denmark

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