Epinephrine

Generic Name: Epinephrine

Brand Names: Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine, Eurneffy

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₃

CAS Number: 51-43-4

Unique Ingredient Identifier: YKH834O4BH

Background: Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new produ...

Indication: Epinephrine injection is indicated in the emergency treatment of type I allergic reactions, including anaphylaxis. It is also used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
...

Associated Conditions: Anaphylaxis, Angioneurotic Edema, Bleeding, Bronchospasm, Complete Heart Block, Hypotension, Idiopathic Anaphylaxis, Laryngotracheobronchitis, Mild Intermittent Asthma, Nasal Congestion, Open Angle Glaucoma (OAG), Respiratory Distress, Severe Asthma, Syncope, Type I Hypersensitivity, Urticaria, Uterine Contractions, Ventricular Fibrillation, Resuscitation in cardiac arrest following anesthetic accidents, Severe hypersensitivity reactions, Unresponsive Asystole, Unresponsive Bradycardia

Associated Therapies: -

Clinical Trials

Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.

Early Phase 1

Completed

Conditions: Knee Prosthesis

Interventions: Drug: Tranexamic Acid
Drug: Adrenalin

First Posted Date: 2014-12-18

Last Posted Date: 2018-01-19

Lead Sponsor: Brugmann University Hospital

Target Recruit Count: 14

Registration Number: NCT02319915

Locations: 🇧🇪
CHU Brugmann, Brussels, Belgium

Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular

Phase 4

Completed

Conditions: Total Hip Arthroplasty

Interventions: Drug: PNB Bupivacaine
Drug: PAI Ropivacaine
Drug: PAI liposomal bupivacaine
Drug: Epinephrine
Drug: Ketorolac

First Posted Date: 2014-09-16

Last Posted Date: 2018-04-19

Lead Sponsor: Mayo Clinic

Target Recruit Count: 165

Registration Number: NCT02242201

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy

Not Applicable

Terminated

Conditions: Laparoscopic Colorectal Resection

Interventions: Procedure: Paravertebral block
Procedure: TAP block
Procedure: Epidural
Drug: Acetaminophen 1g IV
Drug: Dexamethasone 4mg
Drug: Midazolam up to 2mg
Drug: Propofol 1-2.5 mg/kg
Drug: Sevoflurane to keep a bispectral index of between 40-60
Drug: Local infiltration with 10 mL of plain ropivacaine 0.25%
Drug: Lidocaine
Drug: Epinephrine
Drug: Hydromorphone

First Posted Date: 2014-06-17

Last Posted Date: 2017-09-25

Lead Sponsor: Duke University

Target Recruit Count: 17

Registration Number: NCT02164929

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Vasoactive Drugs in Intensive Care Unit

Phase 4

Recruiting

Conditions: Shock

Interventions: Drug: Norepinephrine
Drug: Phenylephrine
Drug: Epinephrine
Drug: Vasopressin

First Posted Date: 2014-04-21

Last Posted Date: 2024-12-09

Lead Sponsor: University of Chicago

Target Recruit Count: 836

Registration Number: NCT02118467

Locations: 🇺🇸
University of Chicago Medical Center, Chicago, Illinois, United States

Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP Pancreatitis

Not Applicable

Completed

Conditions: Post-ERCP Acute Pancreatitis

Interventions: Drug: Rectal Indomethacin
Drug: Epinephrine

First Posted Date: 2014-04-16

Last Posted Date: 2017-11-01

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 948

Registration Number: NCT02116309

Locations: 🇮🇳
Asian Institute of gastroenterology, Hyderabad, Andhra Pradesh, India
🇺🇸
Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
🇮🇳
Apollo Gleneagles Hospitals, Kolkata, West Bengal, India

and more 1 locations