Epinephrine

Generic Name: Epinephrine

Brand Names: Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine, Eurneffy

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₃

CAS Number: 51-43-4

Unique Ingredient Identifier: YKH834O4BH

Background: Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new produ...

Indication: Epinephrine injection is indicated in the emergency treatment of type I allergic reactions, including anaphylaxis. It is also used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
...

Associated Conditions: Anaphylaxis, Angioneurotic Edema, Bleeding, Bronchospasm, Complete Heart Block, Hypotension, Idiopathic Anaphylaxis, Laryngotracheobronchitis, Mild Intermittent Asthma, Nasal Congestion, Open Angle Glaucoma (OAG), Respiratory Distress, Severe Asthma, Syncope, Type I Hypersensitivity, Urticaria, Uterine Contractions, Ventricular Fibrillation, Resuscitation in cardiac arrest following anesthetic accidents, Severe hypersensitivity reactions, Unresponsive Asystole, Unresponsive Bradycardia

Associated Therapies: -

Clinical Trials

Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation

Not Applicable

Completed

Conditions: Hypotension After Reperfusion in Liver Transplantation

Interventions: Drug: epinephrine
Drug: placebo control
Drug: phenylephrine

First Posted Date: 2010-03-04

Last Posted Date: 2012-05-03

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 96

Registration Number: NCT01080625

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia

Phase 2

Active, not recruiting

Conditions: Hairy Cell Leukemia

Interventions: Drug: Rituximab
Drug: Pentostatin
Drug: Bendamustine
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Epinephrine
Drug: Antihistamines
Drug: Corticosteroids
Drug: Bronchodilators
Other: Intravenous (IV) Saline

First Posted Date: 2010-02-01

Last Posted Date: 2024-05-01

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 69

Registration Number: NCT01059786

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Not Applicable

Completed

Conditions: Osteoarthritis,Knee

Interventions: Drug: Ropivacaine
Drug: Toradol
Drug: Clonidine
Drug: Epinephrine

First Posted Date: 2010-01-05

Last Posted Date: 2013-11-08

Lead Sponsor: Towson Orthopaedic Associates

Target Recruit Count: 160

Registration Number: NCT01042093

In-hospital Cardiac Arrest - Dynamics and State Transitions

Completed

Conditions: Death, Sudden, Cardiac
Heart Arrest

First Posted Date: 2009-06-15

Last Posted Date: 2018-09-05

Lead Sponsor: St. Olavs Hospital

Target Recruit Count: 285

Registration Number: NCT00920244

Locations: 🇳🇴
St.Olavs Hospital, Department of Anesthesia, Trondheim, Norway

Periarticular Multimodal Drug Injections in Total Knee Arthroplasty

Phase 4

Completed

Conditions: Osteoarthritis, Knee

Interventions: Drug: ropivacaine
Drug: morphine sulfate
Drug: ketorolac
Drug: epinephrine
Drug: cefuroxime

First Posted Date: 2009-05-14

Last Posted Date: 2013-01-25

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 101

Registration Number: NCT00901628

Locations: 🇰🇷
Joint Reconstruction Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis

Phase 2

Completed

Conditions: Angioedema
Hypotension
Bronchospasm
Anaphylaxis

Interventions: Drug: Epinephrine
Drug: Omalizumab (Xolair)
Drug: Placebos

First Posted Date: 2009-04-29

Last Posted Date: 2019-07-01

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 16

Registration Number: NCT00890162

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Safety of Epidural Fentanyl and Adrenalin During Childbirth

Phase 4

Completed

Conditions: Pregnancy
Pain

Interventions: Drug: adrenalin
Drug: placebo

First Posted Date: 2008-05-28

Last Posted Date: 2016-03-30

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 40

Registration Number: NCT00685672

Locations: 🇳🇴
Division of Anaesthesiology and Intensive Care Medicine, Rikshospitalet University Hospital, Oslo, Norway
🇳🇴
Akershus University Hospital, Lørenskog, Norway