Hydromorphone
- Generic Name
- Hydromorphone
- Brand Names
- Dilaudid, Exalgo, Hydromorph Contin, Hydromorphone Hp Forte
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 466-99-9
- Unique Ingredient Identifier
- Q812464R06
- Background
Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it present...
- Indication
Hydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain. Due to its addictive potential and overdose risk, hydromorphone is only prescribed when other first-line treatments have failed.
...
- Associated Conditions
- Neuropathic Pain, Refractory Chronic Cough, Moderate to severe pain
- Associated Therapies
- -
Satisfactory Analgesia Minimal Emesis in Day Surgeries
- Conditions
- Interventions
- First Posted Date
- 2014-08-22
- Last Posted Date
- 2023-12-11
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 402
- Registration Number
- NCT02223377
- Locations
- 🇨🇦
Hamilton Health Sciences, Hamilton, Ontario, Canada
🇨🇦St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy
- Conditions
- Interventions
- Procedure: Paravertebral blockProcedure: TAP blockProcedure: EpiduralDrug: Acetaminophen 1g IVDrug: Dexamethasone 4mgDrug: Midazolam up to 2mgDrug: Propofol 1-2.5 mg/kgDrug: Sevoflurane to keep a bispectral index of between 40-60Drug: Local infiltration with 10 mL of plain ropivacaine 0.25%Drug: LidocaineDrug: EpinephrineDrug: Hydromorphone
- First Posted Date
- 2014-06-17
- Last Posted Date
- 2017-09-25
- Lead Sponsor
- Duke University
- Target Recruit Count
- 17
- Registration Number
- NCT02164929
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Decreasing Narcotics in Advanced Pelvic Surgery
- First Posted Date
- 2014-04-10
- Last Posted Date
- 2016-08-17
- Lead Sponsor
- Hartford Hospital
- Target Recruit Count
- 138
- Registration Number
- NCT02110719
- Locations
- 🇺🇸
Hartford Hosptial, Hartford, Connecticut, United States
Methadone and Hydromorphone For Spinal Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-04-08
- Last Posted Date
- 2019-09-30
- Lead Sponsor
- NorthShore University HealthSystem
- Target Recruit Count
- 120
- Registration Number
- NCT02107339
- Locations
- 🇺🇸
NorthShore University HealthSystem, Evanston, Illinois, United States
Ketamine Patient-Controlled Analgesia for Acute Pain
- Conditions
- Interventions
- First Posted Date
- 2014-02-14
- Last Posted Date
- 2017-09-21
- Lead Sponsor
- University of Cincinnati
- Target Recruit Count
- 20
- Registration Number
- NCT02062879
- Locations
- 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States
A Comparison Trial Between PCA and Epidural Analgesia for Pectus Excavatum Repair
- First Posted Date
- 2014-02-05
- Last Posted Date
- 2020-06-11
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 62
- Registration Number
- NCT02056301
- Locations
- 🇺🇸
Texas Children't Hospital, Houston, Texas, United States
Multiple Dose Study of Blockade of Opioid Effects by Injections of Buprenorphine in Participants With Opioid Disorder
- Conditions
- Interventions
- First Posted Date
- 2014-01-23
- Last Posted Date
- 2018-04-24
- Lead Sponsor
- Indivior Inc.
- Target Recruit Count
- 39
- Registration Number
- NCT02044094
- Locations
- 🇺🇸
Vince & Associates Clinical Research, Overland Park, Kansas, United States
Postoperative Pain Therapy With Hydromorphone Using TCI-PCA
- First Posted Date
- 2014-01-14
- Last Posted Date
- 2015-07-03
- Lead Sponsor
- University of Erlangen-Nürnberg Medical School
- Target Recruit Count
- 50
- Registration Number
- NCT02035709
- Locations
- 🇩🇪
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
- Conditions
- Interventions
- First Posted Date
- 2013-12-12
- Last Posted Date
- 2016-07-25
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 84
- Registration Number
- NCT02009722
- Locations
- 🇺🇸
Rochester Methodist Hospital, Mayo Clinic, Rochester, Minnesota, United States
Epidural Analgesia Versus IV Analgesia in Lumbar Spine Fusions
- Conditions
- Interventions
- First Posted Date
- 2013-11-19
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Duke University
- Target Recruit Count
- 17
- Registration Number
- NCT01986946
- Locations
- 🇺🇸
Duke University Hospital, Durham, North Carolina, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.