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Oxycodone

Generic Name
Oxycodone
Brand Names
Endocet, Endodan Reformulated May 2009, Nalocet, Oxaydo, Oxy.IR, Oxycontin, Oxyneo, Percocet, Prolate, Rivacocet, Roxicet, Roxicodone, Roxybond, Targin, Targiniq, Xolox, Xtampza
Drug Type
Small Molecule
Chemical Formula
C18H21NO4
CAS Number
76-42-6
Unique Ingredient Identifier
CD35PMG570
Background

Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period. The first oxycodone containing product, Percodan, was approved by the FDA on April 12, 1950.

Indication

Oxycodone is indicated for the treatment of moderate to severe pain. There is also an extended release formulation indicated for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.

Associated Conditions
Severe Acute Pain, Severe Pain, Severe, Chronic Pain, Acute, moderate Pain, Chronic, moderate Pain
Associated Therapies
-
Clinical Trials
Related News

Early Use of Opioid in Radiation Mucositis

Phase 2
Completed
Conditions
Nutrition Disorders
Quality of Life
Interventions
Drug: Oxycodone
First Posted Date
2014-12-05
Last Posted Date
2018-07-17
Lead Sponsor
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Target Recruit Count
200
Registration Number
NCT02309437
Locations
🇨🇳

People's Hospital of Boluo County, Huizhou, Guangdong, China

🇨🇳

Guangzhou Panyu Center Hospital, Guangzhou, Guangdong, China

🇨🇳

Cancer Center Of Guangzhou Medical University, Guangzhou, Guangdong, China

and more 1 locations

Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery

Phase 4
Completed
Conditions
Nausea
Interventions
Drug: Hydromorphone
Drug: Oxycodone
First Posted Date
2014-11-20
Last Posted Date
2017-11-27
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
200
Registration Number
NCT02295124
Locations
🇨🇦

Toronto Western Hospital, Toronto, Ontario, Canada

Clinical Evaluation of the ReLeaf Analgesic Infusion Catheter & Wound Drain

Not Applicable
Withdrawn
Conditions
Low Back Pain
Interventions
Device: ReLeaf catheter
Drug: Saline
Drug: Ropivacaine
Drug: Morphine
Drug: Oxycodone
First Posted Date
2014-11-18
Last Posted Date
2016-01-22
Lead Sponsor
Vital 5, LLC
Registration Number
NCT02293525

A Study of the Abuse Liability Potential of Samidorphan in Healthy, Non-Dependent, Recreational Opioid Users

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
Drug: Placebo
Drug: Samidorphan
Drug: Oxycodone
First Posted Date
2014-08-15
Last Posted Date
2014-12-02
Lead Sponsor
Alkermes, Inc.
Target Recruit Count
59
Registration Number
NCT02218021
Locations
🇺🇸

Alkermes Investigational Site, Overland Park, Kansas, United States

Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Oxycodone
Drug: Naltrexone
First Posted Date
2014-06-18
Last Posted Date
2016-04-04
Lead Sponsor
Pain Therapeutics
Target Recruit Count
17
Registration Number
NCT02165930
Locations
🇺🇸

Pfizer Investigational Site, Overland Park, Kansas, United States

Effect of a Multimodal Pain Regimen on Pain Control, Patient Satisfaction and Narcotic Use in Orthopaedic Trauma Patients

Phase 4
Withdrawn
Conditions
Post Operative Pain Control
Interventions
Drug: Gabapentin
Drug: Acetaminophen
Drug: Celecoxib
Drug: Dexamethasone
Drug: Oxycodone
First Posted Date
2014-06-10
Last Posted Date
2017-05-19
Lead Sponsor
University of North Carolina, Chapel Hill
Registration Number
NCT02160301
Locations
🇺🇸

UNC Chapel Hill Hospital, Chapel Hill, North Carolina, United States

Analgesic Response to Opioid Analgesics in Buprenorphine-Maintained Individuals

Not Applicable
Conditions
Analgesic Response
Interventions
Drug: oral tablet placebo
Drug: sublingual tablet placebo
Drug: morphine sulfate
Drug: buprenorphine
Drug: hydrocodone
Drug: hydromorphone HCI
Drug: oxycodone
First Posted Date
2014-05-13
Last Posted Date
2014-05-13
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
12
Registration Number
NCT02136784
Locations
🇺🇸

UCLA Integrated Substance Abuse Programs Outpatient Clinical Research Center, Los Angeles, California, United States

Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: Oxycodone
First Posted Date
2014-04-21
Last Posted Date
2016-04-04
Lead Sponsor
Pain Therapeutics
Target Recruit Count
34
Registration Number
NCT02117583
Locations
🇺🇸

Pfizer Investigational Site, Overland Park, Kansas, United States

Decreasing Narcotics in Advanced Pelvic Surgery

First Posted Date
2014-04-10
Last Posted Date
2016-08-17
Lead Sponsor
Hartford Hospital
Target Recruit Count
138
Registration Number
NCT02110719
Locations
🇺🇸

Hartford Hosptial, Hartford, Connecticut, United States

A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery

Phase 3
Completed
Conditions
Postoperative Pain
Postoperative Nausea and Vomiting
Interventions
Drug: Targinact
Drug: Oxycodone
Procedure: Laparoscopic segmental colectomy
First Posted Date
2014-04-10
Last Posted Date
2017-03-29
Lead Sponsor
University of Edinburgh
Target Recruit Count
50
Registration Number
NCT02109640
Locations
🇬🇧

Western General Hospital, Edinburgh, United Kingdom

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