Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

NSAID Use and Healing After Tibia Fractures and Achilles Tendon Ruptures

First Posted Date
2019-03-19
Last Posted Date
2019-03-19
Lead Sponsor
University of California, Los Angeles
Target Recruit Count
456
Registration Number
NCT03880981

4-methylpyrazole and Acetaminophen Metabolism

Early Phase 1
Completed
Conditions
Interventions
First Posted Date
2019-03-18
Last Posted Date
2019-09-26
Lead Sponsor
University of Arizona
Target Recruit Count
6
Registration Number
NCT03878693
Locations
🇺🇸

BUMCP - Department of Medical Toxicology, Phoenix, Arizona, United States

Early Treatment Versus Expectant Management of PDA in Preterm Infants

First Posted Date
2019-03-04
Last Posted Date
2022-04-13
Lead Sponsor
Lviv National Medical University
Target Recruit Count
208
Registration Number
NCT03860428
Locations
🇺🇦

Lviv National Medical University, Lviv, Ukraine

Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

First Posted Date
2019-03-01
Last Posted Date
2023-08-01
Lead Sponsor
University of Alabama at Birmingham
Target Recruit Count
60
Registration Number
NCT03859024
Locations
🇺🇸

University of Alabama of Birmingham, Birmingham, Alabama, United States

Preoperative Dose of Co-amoxiclav for Prevention of Postoperative Complications in Dentoalveolar Surgery

First Posted Date
2019-02-18
Last Posted Date
2020-10-06
Lead Sponsor
Taibah University
Target Recruit Count
135
Registration Number
NCT03844776
Locations
🇸🇦

Taibah University, Medina, Saudi Arabia

Efficacy of Paracetamol in Addition to Morphine to Improve Analgesia in the Emergency Department

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-02-18
Last Posted Date
2020-10-19
Lead Sponsor
Bruno Minotti
Target Recruit Count
222
Registration Number
NCT03843281
Locations
🇨🇭

Kantonsspital St.Gallen, Sankt Gallen, Switzerland

Comparison of Drugs on Headache Treatment After ECT Treatment

First Posted Date
2019-02-05
Last Posted Date
2019-02-05
Lead Sponsor
Mustafa Kemal University
Target Recruit Count
225
Registration Number
NCT03830398
Locations
🇹🇷

Mustafa Kemal University Medicine Faculty Anesthesiology Department, Hatay, Turkey

To Study and Evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for Post-operative Pain in Cesarean Section Patients Using Primary Relief v 2.0

First Posted Date
2019-02-04
Last Posted Date
2019-02-05
Lead Sponsor
DyAnsys, Inc.
Target Recruit Count
22
Registration Number
NCT03829774
Locations
🇮🇳

Clinic, Warangal, Telangana, India

Nonopioid Analgesia After Labral Surgery

First Posted Date
2019-01-31
Last Posted Date
2019-01-31
Lead Sponsor
Henry Ford Health System
Target Recruit Count
100
Registration Number
NCT03825809
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

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