Acetaminophen

Generic Name
Acetaminophen
Brand Names
Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone
Drug Type
Small Molecule
Chemical Formula
C8H9NO2
CAS Number
103-90-2
Unique Ingredient Identifier
362O9ITL9D
Background

Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a variety of forms including syrup form, regular tablets, effervescent tablets, injection, suppository, and other forms.

Acetaminophen is often found combined with other drugs in more than 600 over the counter (OTC) allergy medications, cold medications, sleep medications, pain relievers, and other products. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages. Due to the possibility of fatal overdose and liver failure associated with the incorrect use of acetaminophen, it is important to follow current and available national and manufacturer dosing guidelines while this drug is taken or prescribed.

Indication

In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.

Acetaminophen injection is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever.

Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

Associated Conditions
Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain
Associated Therapies
Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

First Posted Date
2019-01-30
Last Posted Date
2024-11-06
Lead Sponsor
St. Louis University
Target Recruit Count
60
Registration Number
NCT03823534
Locations
🇺🇸

Saint Louis University, Saint Louis, Missouri, United States

Nonopioid Analgesia After Arthroscopic Meniscus Surgery

First Posted Date
2019-01-29
Last Posted Date
2023-12-05
Lead Sponsor
Henry Ford Health System
Target Recruit Count
61
Registration Number
NCT03820193
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

First Posted Date
2019-01-28
Last Posted Date
2021-02-11
Lead Sponsor
Henry Ford Health System
Target Recruit Count
62
Registration Number
NCT03818932
Locations
🇺🇸

Henry Ford Health System, Detroit, Michigan, United States

Nonopioid Analgesia After Rotator Cuff Repair

First Posted Date
2019-01-28
Last Posted Date
2024-04-02
Lead Sponsor
Henry Ford Health System
Target Recruit Count
70
Registration Number
NCT03818919
Locations
🇺🇸

Health Ford Health System, Detroit, Michigan, United States

Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia

First Posted Date
2019-01-16
Last Posted Date
2024-07-30
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
18
Registration Number
NCT03805932
Locations
🇺🇸

National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Study in Subjects Undergoing Complete Abdominoplasty

First Posted Date
2018-12-28
Last Posted Date
2024-03-19
Lead Sponsor
Concentric Analgesics
Target Recruit Count
54
Registration Number
NCT03789318
Locations
🇺🇸

Lotus Clinical Research, LLC, Pasadena, California, United States

Pre-emptive Analgesic Administration in Primary Tooth Extraction

First Posted Date
2018-12-24
Last Posted Date
2019-06-18
Lead Sponsor
Tishreen University
Target Recruit Count
66
Registration Number
NCT03786029
Locations
🇸🇾

Tishreen University, Latakia, Syrian Arab Republic

Effects of Preemptive Paracetamol and Ibuprofen on Headache and Myalgia in Patients After Electroconvulsive Therapy

First Posted Date
2018-12-21
Last Posted Date
2019-04-03
Lead Sponsor
Inonu University
Target Recruit Count
60
Registration Number
NCT03783312
Locations
🇹🇷

Erol Karaaslan, Malatya, Türkiye-Türkçe, Turkey

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

First Posted Date
2018-12-20
Last Posted Date
2024-05-17
Lead Sponsor
University of Zurich
Target Recruit Count
90
Registration Number
NCT03781544
Locations
🇨🇭

University Heart Center Zurich, Zurich, Switzerland

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