Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty

Phase 4

Completed

Conditions: Elderly
Total Knee Arthroplasty
Functional Outcome
Femoral Nerve Block
Dexmedetomidine

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2020-11-24

Last Posted Date: 2022-04-20

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 170

Registration Number: NCT04642651

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China
🇨🇳
Beijing Jishuitan Hospital, Beijing, Beijing, China

DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)

Not Applicable

Completed

Conditions: Chronic Insomnia

Interventions: Drug: dexmedetomidine
Drug: saline

First Posted Date: 2020-11-18

Last Posted Date: 2024-04-01

Lead Sponsor: Ruijin Hospital

Target Recruit Count: 64

Registration Number: NCT04635098

Locations: 🇨🇳
Ruijin Hospital, Shanghai, Shanghai, China

Comparison of the Perioperative Effects of Dexmedetomidine and Ketamine Sedation in Septorhinoplasty Operations

Not Applicable

Completed

Conditions: Anesthesia
Intravenous Anesthetic Toxicity

Interventions: Drug: Saline
Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2020-11-13

Last Posted Date: 2020-11-17

Lead Sponsor: Karadeniz Technical University

Target Recruit Count: 63

Registration Number: NCT04628559

Locations: 🇹🇷
Medical School of Karadeniz Technical University, Department of Anesthesiology, Trabzon, Turkey

Effects of Dexmedetomidine on Intraocular Pressure During Scheduled Spine Surgeries

Not Applicable

Recruiting

Conditions: Intraocular Pressure

Interventions: Other: Normal Saline
Drug: Dexmedetomidine

First Posted Date: 2020-11-13

Last Posted Date: 2024-01-31

Lead Sponsor: Attikon Hospital

Target Recruit Count: 60

Registration Number: NCT04628663

Locations: 🇬🇷
2nd Department of Anesthesiology, Attikon University Hospital, Athens, Attiki, Greece

Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy

Phase 4

Completed

Conditions: Hemodynamic Instability
Supratentorial Neoplasms

Interventions: Drug: Dexmedetomidine
Drug: normal saline

First Posted Date: 2020-10-29

Last Posted Date: 2021-03-01

Lead Sponsor: Ain Shams University

Target Recruit Count: 40

Registration Number: NCT04607525

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea

Phase 4

Completed

Conditions: Obstructive Sleep Apnea
Analgesia
Dexmedetomidine
High-flow Nasal Cannula
Sleep Quality

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2020-10-29

Last Posted Date: 2022-12-13

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 152

Registration Number: NCT04608331

Locations: 🇨🇳
Dong-Xin Wang, Beijing, Beijing, China

Dexmedetomidine Versus Ketamine Versus Midazolam in Endoscopic Procedures

Not Applicable

Completed

Conditions: Sedation and Analgesia

Interventions: Drug: Midazolam
Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2020-10-22

Last Posted Date: 2023-01-10

Lead Sponsor: National Cancer Institute, Egypt

Target Recruit Count: 75

Registration Number: NCT04597268

Locations: 🇪🇬
Walaa Y Elsabeeny, Cairo, Egypt

Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period

Not Applicable

Completed

Conditions: Dexmedetomidine
Cardiac Electrophysiology
General Anesthesia
Cardiac Function

Interventions: Drug: Normal saline
Drug: Dexmedetomidine

First Posted Date: 2020-10-06

Last Posted Date: 2021-08-31

Lead Sponsor: Yangzhou University

Target Recruit Count: 81

Registration Number: NCT04577430

Locations: 🇨🇳
the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China

Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric Surgery

Phase 3

Conditions: Surgery
Morbid Obesity

Interventions: Drug: Normal Saline 0.9%
Drug: Ketamine
Drug: Dexmedetomidine

First Posted Date: 2020-10-06

Last Posted Date: 2021-07-28

Lead Sponsor: Ain Shams University

Target Recruit Count: 90

Registration Number: NCT04576975

Locations: 🇪🇬
Ainshams University Hospitals, Cairo, Egypt

Effect of Midazolam and Dexmedetomidine on Heart Function - A Randomized MRI-based Study.

Phase 4

Completed

Conditions: Magnetic Resonance Imaging
Cardiac Function
Sedation

Interventions: Drug: Dexmedetomidine
Drug: Midazolam

First Posted Date: 2020-08-27

Last Posted Date: 2020-08-27

Lead Sponsor: Masaryk Hospital Krajská zdravotní a.s.

Target Recruit Count: 30

Registration Number: NCT04529187

Locations: 🇨🇿
Department of Cardiology, Masaryk Hospital and UJEP, Usti nad Labem, Czech Republic., Ústí Nad Labem, Czechia

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