Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Comparison Between Dexmeditomidine, Midazolam and Ketamine as a Sedative to Help Cannula Insertion in Pediatric Patient

Phase 2

Completed

Conditions: Cannula Site Pain

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Ketamine

First Posted Date: 2021-01-11

Last Posted Date: 2021-05-28

Lead Sponsor: Ain Shams University

Target Recruit Count: 150

Registration Number: NCT04704622

Locations: 🇪🇬
Ain Shams University Hospital, Cairo, EL Abassia, Egypt

Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure - Preliminary Study

Not Applicable

Recruiting

Conditions: Retinoblastoma

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-01-08

Last Posted Date: 2023-04-24

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 60

Registration Number: NCT04700514

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Comparison of Doses of Dexmedetomidine With Bupivacaine in Caudal Block for Duration of Analgesia in Paediatric Infraumblical Surgeries.

Phase 4

Conditions: Pain, Postoperative

Interventions: Drug: Bupivacaine Hydrochloride
Drug: Dexmedetomidine

First Posted Date: 2021-01-07

Last Posted Date: 2021-01-07

Lead Sponsor: Dr. Ruth K.M. Pfau Civil Hospital, Karachi

Target Recruit Count: 162

Registration Number: NCT04700228

Locations: 🇵🇰
Dr. Haris Chohan, Karachi, Sindh, Pakistan

Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics

Phase 1

Completed

Conditions: Vital Signs

Interventions: Drug: Ketamine/ propofol
Drug: Dexmedetomidine

First Posted Date: 2020-12-21

Last Posted Date: 2022-08-05

Lead Sponsor: Ain Shams University

Target Recruit Count: 40

Registration Number: NCT04678050

Locations: 🇪🇬
Ain Shams University, Cairo, Abassia, Egypt

Dexmedetomidine Alleviates Postoperative Delirium After Brain Tumor Resections

Not Applicable

Completed

Conditions: Dexmedetomidine
Postoperative Delirium

Interventions: Drug: 0.9% saline
Drug: Dexmedetomidine

First Posted Date: 2020-12-19

Last Posted Date: 2022-04-04

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 260

Registration Number: NCT04674241

Locations: 🇨🇳
PLA General Hospital, Beijing, China
🇨🇳
Beijing TianTan Hospital,Capital Medical University, Beijing, Beijing,China, China

Dexmedetomidine Facilitate Analgesia

Phase 4

Completed

Conditions: Lower Limb Fracture
Nerve Block

Interventions: Drug: Midazolam
Drug: Dexmedetomidine

First Posted Date: 2020-12-19

Last Posted Date: 2021-08-05

Lead Sponsor: China International Neuroscience Institution

Target Recruit Count: 181

Registration Number: NCT04675372

Locations: 🇨🇳
China International Neuroscience, Beijing, Beijing, China

Subtenon and Intravenous Dexmedetomidine Effect on Patients Undergoing Cataract Surgery

Phase 3

Conditions: Acute Postoperative Pain

Interventions: Drug: Dexmedetomidine
Drug: lidocaine 2%
Drug: bupivacine 0.5%
Drug: Normal saline

First Posted Date: 2020-12-16

Last Posted Date: 2021-02-25

Lead Sponsor: Menoufia University

Target Recruit Count: 75

Registration Number: NCT04668456

Locations: 🇪🇬
Sadik A Sadik, Shibīn Al Kawm, Menoufiya, Egypt
🇪🇬
Ashraf magdy Eskandr, Shibīn Al Kawm, Menoufiya, Egypt
🇪🇬
Osama A Elmorsy, Shibīn Al Kawm, Menoufiya, Egypt