Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effect of Dexmedetomidine on Perioperative Internal Environment and Rehabilitation of Patients Undergoing Gastrointestinal Malignant Tumor Resection

Not Applicable

Completed

Conditions: Dexmedetomidine
Perioperative
Electrolyte

Interventions: Drug: Normal saline
Drug: Dexmedetomidine

First Posted Date: 2021-02-25

Last Posted Date: 2021-11-30

Lead Sponsor: Yangzhou University

Target Recruit Count: 140

Registration Number: NCT04771637

Locations: 🇨🇳
the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China

Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block

Not Applicable

Completed

Conditions: Dexamethasone
Dexmedetomidine
Nerve Block

Interventions: Drug: Dexamethasone and dexmedetomidine
Drug: Dexmedetomidine
Other: Ultrasound-guided lumbar erector spinae plane block
Other: PCIA

First Posted Date: 2021-02-23

Last Posted Date: 2022-03-29

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 120

Registration Number: NCT04767256

Locations: 🇨🇳
Union Hospital, Wuhan, Hubei, China

The Effect of Dexmedetomidine on Kidney Function in EVAR

Not Applicable

Conditions: Acute Kidney Injury
Dexmedetomidine
Endovascular Aortic Repair

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-02-23

Last Posted Date: 2021-04-28

Lead Sponsor: University of Thessaly

Target Recruit Count: 200

Registration Number: NCT04766047

Locations: 🇬🇷
Univeristy of Thessaly, Larissa, Thessaly, Greece

Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients

Phase 4

Conditions: Critical Illness
Delirium

Interventions: Drug: Clonidine
Drug: Dexmedetomidine

First Posted Date: 2021-02-17

Last Posted Date: 2021-02-17

Lead Sponsor: Erasme University Hospital

Target Recruit Count: 50

Registration Number: NCT04758936

Locations: 🇧🇪
Clinique Saint-Pierre, Ottignies, Belgium
🇧🇪
CUB Erasme Hospital ULB, Bruxelles, Belgium
🇧🇪
Civil hospital Marie Curie, Charleroi, Belgium