Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

The Effect of Dexmedetomidine During Opioid Free Anesthesia on Postoperative Recovery After Gastrectomy

Not Applicable

Completed

Conditions: Gastric Cancer

Interventions: Drug: Dexmedetomidine
Drug: Remifentanil

First Posted Date: 2020-08-27

Last Posted Date: 2022-06-23

Lead Sponsor: Gangnam Severance Hospital

Target Recruit Count: 68

Registration Number: NCT04529135

Locations: 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of

Opioid-Free Anesthetic for Tonsillectomy

Phase 4

Terminated

Conditions: Tonsillitis
Opioid Use
Sleep Disorder
Surgery
Anesthesia

Interventions: Drug: Ketorolac
Drug: Morphine
Drug: Fentanyl
Drug: Dexmedetomidine

First Posted Date: 2020-08-27

Last Posted Date: 2024-12-20

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 35

Registration Number: NCT04528173

Locations: 🇺🇸
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸
University of Tennessee Health Science Center; St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Evaluating Stress Response and Anxiety Score in Paediatric Patients

Phase 2

Completed

Conditions: Anesthesia
Anxiety and Fear

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2020-08-26

Last Posted Date: 2021-10-25

Lead Sponsor: Universiti Sains Malaysia

Target Recruit Count: 60

Registration Number: NCT04526652

Locations: 🇲🇾
Hospital Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia

Intraperitoneal Dexmedetomidine Versus Ketamine With Bupivacaine For Postoperative Analgesia

Not Applicable

Completed

Conditions: Obesity

Interventions: Drug: normal saline
Drug: dexmedetomidine
Drug: Ketamine

First Posted Date: 2020-08-25

Last Posted Date: 2023-04-27

Lead Sponsor: Zagazig University

Target Recruit Count: 60

Registration Number: NCT04525274

Locations: 🇪🇬
faculty of medicine, Zagazig university, Zagazig, Elsharqya, Egypt

Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery

Not Applicable

Conditions: Aged
Colorectal Neoplasms

Interventions: Procedure: Transversus abdominis plane block using ropivacaine
Procedure: Transversus abdominis plane block using saline
Drug: Saline
Drug: Dexmedetomidine