Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Determining the Pharmacogenetic Basis of Non-responsiveness to the Sedative Effects of Dexmedetomidine in Children

Conditions: Procedural Anxiety
Dexmedetomidine
Pharmacogenetic Study

Interventions: Drug: Precedex

First Posted Date: 2020-07-15

Last Posted Date: 2022-03-16

Lead Sponsor: Hong Kong Children's Hospital

Target Recruit Count: 100

Registration Number: NCT04471402

Locations: 🇭🇰
Hong Kong Children's Hospital, Hong Kong, Hong Kong

Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal

Phase 1

Completed

Conditions: Opioid Withdrawal

Interventions: Drug: Dexmedetomidine
Drug: Placebo

First Posted Date: 2020-07-14

Last Posted Date: 2023-10-26

Lead Sponsor: BioXcel Therapeutics Inc

Target Recruit Count: 225

Registration Number: NCT04470050

Locations: 🇺🇸
BioXcel Clinical Research Site, New York, New York, United States

The Effect of Intraoperative Dexmedetomidine on Postoperative Morphine Requirements After Breast Cancer Surgery

Not Applicable

Recruiting

Conditions: Morphine Consumption

Interventions: Drug: Dexmedetomidine
Drug: placebo

First Posted Date: 2020-07-01

Last Posted Date: 2024-01-17

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 60

Registration Number: NCT04454515

Locations: 🇨🇳
National Taiwan University Cancer Center, Taipei, Taiwan

Efficacy of Dexmedetomidine Versus Morphine as an Adjunct to Bupivacaine in Caudal Anesthesia.

Not Applicable

Completed

Conditions: Anesthesia, Local

Interventions: Drug: Dexmedetomidine
Drug: Morphine

First Posted Date: 2020-06-24

Last Posted Date: 2020-12-22

Lead Sponsor: Cairo University

Target Recruit Count: 50

Registration Number: NCT04445636

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl

Not Applicable

Completed

Conditions: Analgesia

Interventions: Drug: Bupivacain
Drug: Dexmedetomidine
Drug: Fentanyl

First Posted Date: 2020-06-23

Last Posted Date: 2021-01-25

Lead Sponsor: Zagazig University

Target Recruit Count: 45

Registration Number: NCT04442906

Locations: 🇪🇬
Zagazig university, Zagazig, Egypt

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

Early Phase 1

Recruiting

Conditions: Healthy
Vasoconstriction
Vasodilation
Obesity

Interventions: Other: Hypoxia Exposure
Drug: Phenylephrine
Drug: Dexmedetomidine
Drug: Phentolamine
Drug: Norepinephrine

First Posted Date: 2020-06-18

Last Posted Date: 2024-05-03

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 104

Registration Number: NCT04436731

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

Dexmedetomidine Versus Sevoflurane in Children With Anticipated Difficult Intubation

Phase 2

Conditions: Craniofacial Abnormalities
Mandibular Hypoplasia

Interventions: Drug: sevoflurane
Drug: dexmedetomidine

First Posted Date: 2020-06-11

Last Posted Date: 2020-06-12

Lead Sponsor: Alexandria University

Target Recruit Count: 40

Registration Number: NCT04426552

Locations: 🇪🇬
Rehab Abd Elraof Abd Elaziz, Alexandria, Smouha, Egypt

Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery

Not Applicable

Completed

Conditions: Caudal Analgesia for Lumosacral Spine Surgeries

Interventions: Drug: Bupivacaine
Drug: Dexamethasone
Drug: Dexmedetomidine
Drug: Hyalouridinase

First Posted Date: 2020-06-02

Last Posted Date: 2021-05-19

Lead Sponsor: Ain Shams University

Target Recruit Count: 60

Registration Number: NCT04411329

Locations: 🇪🇬
Sanaa Farag Mahmoud, Cairo, New Cairo, Egypt
🇪🇬
Ainshams hospitals, Cairo, Egypt

Dexmedetomidine for Prevention of Postoperative Delirium After Intracranial Operation for Brain Tumor

Phase 4

Conditions: Central Nervous System Diseases

Interventions: Drug: Dexmedetomidine
Drug: Normal saline

First Posted Date: 2020-05-22

Last Posted Date: 2021-01-28

Lead Sponsor: Capital Medical University

Target Recruit Count: 700

Registration Number: NCT04399343

Locations: 🇨🇳
Intensive Care Unit, Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China

Dexmedetomidine-Propofol and Ketamine-Propofol During Upper Gastrointestinal System Sedation

Completed

Conditions: Anesthesia; Reaction

First Posted Date: 2020-05-22

Last Posted Date: 2020-05-22

Lead Sponsor: Yuzuncu Yıl University

Target Recruit Count: 60

Registration Number: NCT04399226

Locations: 🇹🇷
Van Yuzuncu Yil University, VAN, Tuşba, Turkey

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