Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Comparison of Tramadol and Dexmedetomidine in the Prevention of Urinary Catheter Discomfort in Urinary Surgery

Not Applicable

Completed

Conditions: Catheter Related Complication

Interventions: Other: control
Drug: Dexmedetomidine
Drug: Tramadol

First Posted Date: 2020-03-18

Last Posted Date: 2021-11-09

Lead Sponsor: Ankara Diskapi Training and Research Hospital

Target Recruit Count: 135

Registration Number: NCT04314050

Locations: 🇹🇷
Diskapi Training and Research Hospital, Ankara, Turkey

Median Effective Dose of Dexmedetomidine in Elective Upper Limb Lidocaine Intravenous Regional Anesthesia

Phase 4

Completed

Conditions: Intravenous Drug Usage

Interventions: Drug: Dexmedetomidine

First Posted Date: 2020-03-11

Last Posted Date: 2020-03-11

Lead Sponsor: South Valley University

Target Recruit Count: 81

Registration Number: NCT04304157

Locations: 🇪🇬
South Valley University, Qinā, Egypt

Magnesium Sulfate Versus Dexmedetomidine on Anesthesia Awakening.

Phase 3

Completed

Conditions: Cholecystectomy

Interventions: Drug: Sham treatment
Drug: Dexmedetomidine
Drug: Magnesium Sulfate

First Posted Date: 2020-03-09

Last Posted Date: 2023-01-11

Lead Sponsor: University of Sao Paulo General Hospital

Target Recruit Count: 90

Registration Number: NCT04300985

Locations: 🇧🇷
Hospital das Clínicas - Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Brazil

Intranasal Dexmedetomidine vs Oral Triclofos Sodium for EEG in Children With Autism

Phase 4

Conditions: Autistic Disorder

Interventions: Drug: Dexmedetomidine
Drug: Triclofos 100 MG/ML

First Posted Date: 2020-02-17

Last Posted Date: 2020-02-17

Lead Sponsor: Rabin Medical Center

Target Recruit Count: 200

Registration Number: NCT04270708

Different Premedication in Pediatric Patients

Not Applicable

Completed

Conditions: Agitation

Interventions: Drug: Saline
Drug: midazolam
Drug: dexmedetomidine

First Posted Date: 2020-02-12

Last Posted Date: 2022-05-11

Lead Sponsor: Eye & ENT Hospital of Fudan University

Target Recruit Count: 320

Registration Number: NCT04266340

Locations: 🇨🇳
Department of Anesthesiology, The Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, Shanghai, China

Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome

Phase 4

Completed

Conditions: Brain Tumor
Metabolic Disturbance
Inflammatory Response
Oxygen Deficiency

Interventions: Other: Normal saline
Drug: Dexmedetomidine

First Posted Date: 2020-02-12

Last Posted Date: 2022-02-15

Lead Sponsor: Georgia Tsaousi

Target Recruit Count: 54

Registration Number: NCT04266665

Locations: 🇬🇷
AHEPA University Hospital, Thessaloniki, Greece

Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans

Phase 4

Completed

Conditions: MRI Sedation

Interventions: Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2020-01-23

Last Posted Date: 2022-11-16

Lead Sponsor: Pfizer

Target Recruit Count: 128

Registration Number: NCT04237792

Locations: 🇯🇵
National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan
🇺🇸
Children's Healthcare of Atlanta-Egleston, Atlanta, Georgia, United States
🇺🇸
University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, United States

and more 20 locations