Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine or Fentanyl as Additives to Epidural Levobupivacaine in Painless Labor

Phase 4

Completed

Conditions: Dexmedetomidine
Levobupivacaine
Painless Labor
Epidural Analgesia
Fentanyl

Interventions: Drug: levobupivacaine
Drug: Dexmedetomidine
Drug: Fentanyl

First Posted Date: 2020-05-21

Last Posted Date: 2022-03-28

Lead Sponsor: Tanta University

Target Recruit Count: 90

Registration Number: NCT04397406

Locations: 🇪🇬
Tanta University Hospitals, Tanta, Gharbiya, Egypt

Extension of Analgesia by Combined Injection of Dexamethasone and Dexmedetomidine After Arthroscopic Shoulder Surgery

Phase 4

Completed

Conditions: Analgesia

Interventions: Drug: Dexmedetomidine
Drug: Ropivacaine
Drug: Dexamethasone

First Posted Date: 2020-05-19

Last Posted Date: 2022-01-04

Lead Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche

Target Recruit Count: 122

Registration Number: NCT04394481

Locations: 🇫🇷
Hôpital privé jean Mermoz, Lyon, France

Comparison Between Intrathecal and Intravenous Dexmedetomidine

Not Applicable

Completed

Conditions: Postoperative Analgesia

Interventions: Drug: Dexmedetomidine

First Posted Date: 2020-05-05

Last Posted Date: 2020-05-07

Lead Sponsor: Suez Canal University

Target Recruit Count: 70

Registration Number: NCT04374318

Locations: 🇪🇬
Suez Canal University, Ismailia, Egypt

Association Between Anesthetic Drugs for General Anesthesia and Postoperative Intelligence/behavioral Assessment Results in Children

Not Applicable

Active, not recruiting

Conditions: Anesthesia and Neurotoxicity

Interventions: Drug: Sevoflurane
Drug: dexmedetomidine
Drug: remifentanil

First Posted Date: 2020-04-28

Last Posted Date: 2024-11-19

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 400

Registration Number: NCT04364945

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Other, Korea, Republic of

a Phase III Trial of Safety and Efficacy of Premedication With Dexmedetomidine and Midazolam in Pediatric Patients

Phase 3

Recruiting

Conditions: Perioperative/Postoperative Complications
Anxiety State

Interventions: Other: Placebo
Drug: Midazolam
Drug: Dexmedetomidine

First Posted Date: 2020-04-22

Last Posted Date: 2023-11-24

Lead Sponsor: King Faisal Specialist Hospital & Research Center

Target Recruit Count: 80

Registration Number: NCT04356638

Locations: 🇸🇦
King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia

Effects of Dexmedetomidine on Microcirculation and Residual Kidney Function in Kidney Donors

Phase 4

Conditions: Microcirculation
Kidney Transplant

Interventions: Drug: Dexmedetomidine

First Posted Date: 2020-04-15

Last Posted Date: 2022-08-17

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 120

Registration Number: NCT04346290

Locations: 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan

Comparison of Caudal Block Versus Dexmedetomidine Infusion in Pediatric Patients Undergoing Hypospadias Repair Surgery

Not Applicable

Completed

Conditions: Dexmedetomidine Infusion
Hypospadias Repair Surgery
Pediatric

Interventions: Procedure: caudal block
Drug: Dexmedetomidine

First Posted Date: 2020-04-02

Last Posted Date: 2023-11-24

Lead Sponsor: Tanta University

Target Recruit Count: 135

Registration Number: NCT04331418

Locations: 🇪🇬
Ahmed Abdelrahman, Tanta, Egypt

Implications of Anesthetics on Sleep Consolidation

Phase 4

Terminated

Conditions: Sleep

Interventions: Drug: Dexmedetomidine

First Posted Date: 2020-04-01

Last Posted Date: 2023-02-24

Lead Sponsor: University of Chicago

Target Recruit Count: 9

Registration Number: NCT04329091

Locations: 🇺🇸
University of Chicago Medicine, Chicago, Illinois, United States

the Effect of Dexmedetomidine and Magnesium Sulfate in Open Resection of Pheochromocytoma

Phase 2

Completed

Conditions: Pheochromocytoma

Interventions: Drug: General anesthetic
Drug: Dexmedetomidine

First Posted Date: 2020-03-25

Last Posted Date: 2021-09-01

Lead Sponsor: National Cancer Institute, Egypt

Target Recruit Count: 30

Registration Number: NCT04320589

Locations: 🇪🇬
Department of Anesthesia and Pain medicine.National Cancer Institute, Cairo, Egypt

Dexmedetomidine Versus Fentanyl as Adjuvants to Bupivacaine in Ultrasound Guided Transversus Abdominis Plane Block

Not Applicable

Conditions: Pain

Interventions: Drug: Dexmedetomidine
Drug: Bupivacaine
Drug: Fentanyl

First Posted Date: 2020-03-23

Last Posted Date: 2020-03-23

Lead Sponsor: Beni-Suef University

Target Recruit Count: 60

Registration Number: NCT04318158

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