Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.

Phase 4

Terminated

Conditions: Postoperative Pain

Interventions: Procedure: Continuous Erector Spinae Plane Nerve Block
Procedure: Single Erector Spinae Plane Nerve Block
Procedure: Continuous Quadratus Lumborum Nerve Block
Procedure: Single Quadratus Lumborum Nerve Block
Drug: Lidocaine IV
Drug: Ropivacaine 0.5% Injectable Solution
Drug: Lidocaine
Drug: Dexamethasone
Drug: Dexmedetomidine

First Posted Date: 2019-12-23

Last Posted Date: 2023-09-13

Lead Sponsor: Jeremy Kearns

Target Recruit Count: 17

Registration Number: NCT04208516

Locations: 🇺🇸
UPMC Shadyside Hospital, Pittsburgh, Pennsylvania, United States

Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine

Not Applicable

Active, not recruiting

Conditions: Sleep
Sedation Complication

Interventions: Radiation: MRI
Diagnostic Test: Quantitative Sensory Testing (QST)
Diagnostic Test: Home sleep study
Other: Acoustic stimulation (65db) up-slope of EEG with QST
Other: Acoustic stimulation (65db) down-slope of EEG with QST
Other: 0 db with QST
Drug: Dexmedetomidine
Other: Breathe-Squeeze Task

First Posted Date: 2019-12-20

Last Posted Date: 2022-12-02

Lead Sponsor: Washington University School of Medicine

Target Recruit Count: 20

Registration Number: NCT04206059

Locations: 🇺🇸
Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, Missouri, United States

Dexmedetomidine and Outcomes of Elderly Admitted to ICU After Surgery

Not Applicable

Recruiting

Conditions: Surgery
Overall Survival
Elderly
Intensive Care Unit
Dexmedetomidine

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2019-12-19

Last Posted Date: 2023-09-21

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1410

Registration Number: NCT04204798

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China

Lymphatic System Health in Alzheimer's Disease

Phase 1

Withdrawn

Conditions: Alzheimer Disease

Interventions: Drug: Dexmedetomidine

First Posted Date: 2019-12-19

Last Posted Date: 2022-09-28

Lead Sponsor: Neurological Associates of West Los Angeles

Registration Number: NCT04205539

Locations: 🇺🇸
Westwood Open MRI, Los Angeles, California, United States
🇺🇸
Neurological Associates of West Los Angeles, Santa Monica, California, United States