Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy

Not Applicable

Completed

Conditions: Sepsis-Associated Encephalopathy

Interventions: Drug: Propofol or Midazolam
Drug: Dexmedetomidine
Diagnostic Test: Blood sampling

First Posted Date: 2019-09-03

Last Posted Date: 2023-02-13

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 70

Registration Number: NCT04076826

Locations: 🇨🇭
Inselspital, Bern University Hospital, Bern, Switzerland

Comparison of Analgesic Requirements in Patients Receiving Nuss Operation Using 2 Different Anesthetic Adjuvants

Not Applicable

Conditions: Chest Wall Disorder

Interventions: Drug: Dexmedetomidine

First Posted Date: 2019-08-29

Last Posted Date: 2020-03-20

Lead Sponsor: Jung Min Koo

Target Recruit Count: 62

Registration Number: NCT04073758

Locations: 🇰🇷
Jung Min Koo, Seoul, Korea, Republic of

Memory & Conditioning Under Anesthesia

Phase 1

Completed

Conditions: Anesthesia
Pain

Interventions: Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl
Device: Peripheral Nerve Stimulation
Drug: Placebo

First Posted Date: 2019-08-20

Last Posted Date: 2024-07-01

Lead Sponsor: Keith M. Vogt, MD, PhD

Target Recruit Count: 125

Registration Number: NCT04062123

Locations: 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Dexmedetomidine Versus Nalbuphine in Prevention of Emergence Agitation Following Adenotonsillectomy in Pediatrics

Phase 1

Conditions: Emergence Delirium

Interventions: Drug: Dexmedetomidine
Drug: Nalbuphine
Device: infusion pump

First Posted Date: 2019-08-16

Last Posted Date: 2019-08-20

Lead Sponsor: Ain Shams University

Target Recruit Count: 120

Registration Number: NCT04058899

Locations: 🇪🇬
Ain Shams University, Cairo, Egypt

Comparision of Different Doses of Dexmedetomidine With Low Dose Bupivacaine in Selective Spinal Anesthesia.

Phase 4

Conditions: Drug Effect

Interventions: Other: placebo
Drug: Dexmedetomidine

First Posted Date: 2019-07-30

Last Posted Date: 2019-08-21

Lead Sponsor: Services Institute of Medical Sciences, Pakistan

Target Recruit Count: 75

Registration Number: NCT04037774

Locations: 🇵🇰
Services Institute of Medical Sciences, Lahore, Punjab, Pakistan

Effect of Dexmedetomidine on the Duration of Pain Control in ESP Block for Breast Surgery

Phase 4

Conditions: Breast Cancer
Mastectomy
Axillary Lymph Node Dissection
Pain, Postoperative

Interventions: Drug: Dexmedetomidine

First Posted Date: 2019-07-23

Last Posted Date: 2021-02-23

Lead Sponsor: Lebanese American University

Target Recruit Count: 44

Registration Number: NCT04029467

Locations: 🇱🇧
Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon

The Study of Different Sedative Medications in Monitored Anesthesia Care During Eye Surgery With Local Anesthesia

Not Applicable

Conditions: Balanced Anesthesia
Adjuvants,Anesthesia

Interventions: Drug: Dexmedetomidine
Drug: Midazolam

First Posted Date: 2019-07-12

Last Posted Date: 2020-11-03

Lead Sponsor: Eye & ENT Hospital of Fudan University

Target Recruit Count: 150

Registration Number: NCT04018703

Locations: 🇨🇳
Eye, Ear, Nose and Throat Hospital, Shanghai, Shanghai, China

The PATHFINDER Study: A Feasibility Trial

Early Phase 1

Completed

Conditions: Delirium
Coronary Artery Disease

Interventions: Drug: Ropivacaine
Drug: Ketamine
Drug: Remifentanil
Drug: Dexmedetomidine
Drug: Rocuronium
Drug: Propofol
Drug: Sevoflurane
Device: EEG monitoring

First Posted Date: 2019-07-11

Last Posted Date: 2021-01-28

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 22

Registration Number: NCT04016740

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Effect of Dexmedetomidine on the Inflammatory Response After One-lung Ventilation

Not Applicable

Completed

Conditions: Lung Cancer

Interventions: Drug: Dexmedetomidine

First Posted Date: 2019-07-05

Last Posted Date: 2019-07-05

Lead Sponsor: Seoul St. Mary's Hospital

Target Recruit Count: 40

Registration Number: NCT04007341

Locations: 🇰🇷
Seoul St.Mary's Hospital, Seoul, Korea, Republic of

Study on Cerebral Protection of Dexmedetomidine for Patients With Traumatic Brain Injury

Phase 4

Conditions: Traumatic Brain Injury

Interventions: Drug: Dexmedetomidine
Drug: Midazolam

First Posted Date: 2019-07-02

Last Posted Date: 2019-07-02

Lead Sponsor: Xiangya Hospital of Central South University

Target Recruit Count: 82

Registration Number: NCT04006054

Locations: 🇨🇳
Xiangya Hospital Central South University, Changsha, Hunan, China

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