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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

The Neuroprotection Effect of Dexmedetomidine

Not Applicable
Conditions
Dexmedetomidine
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2019-04-25
Last Posted Date
2019-04-25
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
70
Registration Number
NCT03927963

Conscious Sedation for Outpatient Colonoscopy

Phase 2
Completed
Conditions
Conscious Sedation
Interventions
Drug: Dexmedetomidine
Drug: Propofol
Drug: Remifentanil
First Posted Date
2019-04-24
Last Posted Date
2021-01-08
Lead Sponsor
Menoufia University
Target Recruit Count
80
Registration Number
NCT03925779
Locations
🇪🇬

Faculty of Medicine, Cairo, Shebin El-kom, Egypt

Intranasal Injection of Dexmedetomidine and Bupivacaine in Septoplasty Surgeries

Phase 4
Conditions
Intranasal Dexmedetomidine
Intranasal Bupivacaine
Septoplasty Surgeries
Interventions
Drug: Dexmedetomidine
Drug: Bupivacaine
First Posted Date
2019-04-24
Last Posted Date
2019-08-01
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT03926663
Locations
🇪🇬

Faculty of medicine,Beni-Suef University, Banī Suwayf, Egypt

Dexmetomidine in Children Undergoing General Anaesthesia

Not Applicable
Completed
Conditions
Anesthesia
Interventions
Drug: Dexmedetomidine
Other: 0.9% saline
First Posted Date
2019-04-22
Last Posted Date
2020-11-06
Lead Sponsor
Attikon Hospital
Target Recruit Count
60
Registration Number
NCT03923075
Locations
🇬🇷

2nd Department of Anesthesiology, Attikon University Hospital, Athens, Attiki, Greece

Effect of Dexmedetomidine on Nol-Index Guided Remifentanil Analgesia

Not Applicable
Completed
Conditions
Anesthesia
Perioperative/Postoperative Complications
Nociceptive Pain
Opioid Use
Interventions
Drug: sodium chloride
Drug: Dexmedetomidine
Drug: Remifentanil
First Posted Date
2019-04-11
Last Posted Date
2020-04-03
Lead Sponsor
Erasme University Hospital
Target Recruit Count
58
Registration Number
NCT03912740
Locations
🇧🇪

Erasme University Hospital, Bruxelles, Belgium

Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy

Phase 4
Conditions
Obstructive Sleep Apnea
Interventions
Drug: Propofol Fresenius
Drug: Dexmedetomidine
First Posted Date
2019-03-27
Last Posted Date
2019-03-29
Lead Sponsor
Ospedale Monsignor R. Dimiccoli, Barletta
Target Recruit Count
28
Registration Number
NCT03892122
Locations
🇮🇹

U.O.C. Otorinolaringoiatria Ospedale Di Barletta, Barletta, BAT, Italy

Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction

Phase 1
Conditions
Cognitive Dysfunction
Interventions
Drug: Dexmedetomidine
Drug: Esmolol Hydrochloride
First Posted Date
2019-03-27
Last Posted Date
2019-03-27
Lead Sponsor
Beni-Suef University
Target Recruit Count
58
Registration Number
NCT03892512
Locations
🇪🇬

Beni-Suef University Hospital, Banī Suwayf, Egypt

Sedation With Dexmedetomidine Versus Remifentanil in Urogynecological Surgery Under Spinal Anaesthesia

Phase 3
Conditions
Vaginal Hysterectomy
Suburethral Slings
Interventions
Drug: Dexmedetomidine
Drug: Remifentanil
First Posted Date
2019-03-20
Last Posted Date
2019-10-14
Lead Sponsor
University of Athens
Target Recruit Count
50
Registration Number
NCT03883347
Locations
🇬🇷

Aretaieio Hospital, University of Athens, Athens, Attiki, Greece

The Deep Sedation for Ablation Study

Phase 4
Completed
Conditions
Sedation
Propofol
Dexmedetomidine
Atrial Fibrillation
Ablation
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2019-02-19
Last Posted Date
2021-01-25
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
160
Registration Number
NCT03844841
Locations
🇨🇭

Department of Cardiology, University Hospital Inselspital Bern, Bern, Bern (Kanton), Switzerland

Dexmedetomidine Intra Venous Arthroplasty

Phase 3
Completed
Conditions
Primary Total Knee Arthroplasty
Interventions
Drug: sodium chloride 0.9%
Drug: Dexmedetomidine
First Posted Date
2019-02-07
Last Posted Date
2020-02-07
Lead Sponsor
CMC Ambroise Paré
Target Recruit Count
94
Registration Number
NCT03834129
Locations
🇫🇷

Clinique Médipôle Garonne, Toulouse, Haute-Garonne, France

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