Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

The Effects of Mild Sedation on Motor Function Networks in Patients With Brian Gliomas

Not Applicable

Recruiting

Conditions: Brain Glioma

Interventions: Drug: Midazolam
Drug: Dexmedetomidine

First Posted Date: 2019-06-12

Last Posted Date: 2023-07-27

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 100

Registration Number: NCT03984240

Locations: 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing, China

Sedation Strategies for Diagnostic Bronchoscopy 2

Not Applicable

Conditions: Bronchoscopy
Sedation

Interventions: Drug: Midazolam
Drug: Fentanyl
Drug: Dexmedetomidine
Drug: Remifentanil
Drug: Propofol

First Posted Date: 2019-06-12

Last Posted Date: 2019-06-14

Lead Sponsor: Changhai Hospital

Target Recruit Count: 200

Registration Number: NCT03983889

Locations: 🇨🇳
Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China

Sedation Strategies for Therapeutic Bronchoscopy 2

Not Applicable

Conditions: Bronchoscopy
Sedation

Interventions: Device: Laryngeal mask
Drug: Dexmedetomidine
Drug: Remifentanil

First Posted Date: 2019-06-12

Last Posted Date: 2019-06-14

Lead Sponsor: Changhai Hospital

Target Recruit Count: 80

Registration Number: NCT03983915

Locations: 🇨🇳
Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China

The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Recovery in Patients Undergoing Robot or Laparoscopic Assisted Gastrectomy

Not Applicable

Completed

Conditions: Gastric Cancer
Gastrostomy

Interventions: Drug: dexmedetomidine
Drug: saline

First Posted Date: 2019-05-23

Last Posted Date: 2020-09-28

Lead Sponsor: Yonsei University

Target Recruit Count: 84

Registration Number: NCT03960775

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of

Intranasal Dexmedetomidine Dose-finding Study

Phase 2

Completed

Conditions: Laceration Repair

Interventions: Drug: Dexmedetomidine

First Posted Date: 2019-05-21

Last Posted Date: 2022-04-07

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 55

Registration Number: NCT03957304

Locations: 🇨🇦
London Health Sciences Centre, London, Ontario, Canada

Dexmedetomidine and Delirium in Elderly Patients

Not Applicable

Conditions: Delirium, Dexmedetomidine, Postoperative PCA

Interventions: Drug: Dexmedetomidine
Drug: Fentanyl-based PCA infusion

First Posted Date: 2019-05-06

Last Posted Date: 2022-03-31

Lead Sponsor: Korea University Guro Hospital

Target Recruit Count: 60

Registration Number: NCT03938831

Locations: 🇰🇷
KoreaUniversity Guro Hospital, Seoul, Guro-ku, Korea, Republic of

DOSE Trial of Opioid Sparing Effect

Phase 1

Terminated

Conditions: Mechanical Ventilation Complication
Critically Ill
Dexmedetomidine

Interventions: Drug: Fentanyl
Drug: Dexmedetomidine

First Posted Date: 2019-05-06

Last Posted Date: 2021-11-05

Lead Sponsor: Duke University

Target Recruit Count: 30

Registration Number: NCT03938857

Locations: 🇺🇸
Rainbow Babies and Children's Hospital, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States
🇺🇸
MetroHealth System, Case CTSA, Cleveland, Ohio, United States
🇺🇸
Arkansas Children's Hospital, Little Rock, Arkansas, United States

and more 16 locations