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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Safety, Tolerability and Efficacy of DEXDOR in Pediatric Patients in ICU

Phase 4
Completed
Conditions
ICU Sedation
Interventions
Drug: Dexmedetomidine
First Posted Date
2019-01-23
Last Posted Date
2019-01-23
Lead Sponsor
Orion Corporation, Orion Pharma
Target Recruit Count
60
Registration Number
NCT03813277
Locations
🇷🇺

State Federal-Funded Educational Institution of, Moscow, Russian Federation

Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels.

Phase 4
Completed
Conditions
Bariatric Surgery Candidate
Glucose Intolerance
Insulin Resistance
Interventions
Drug: 0.9% Sodium-chloride
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Morphine Sulfate
First Posted Date
2019-01-18
Last Posted Date
2020-10-01
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
40
Registration Number
NCT03809182

Intra-nasal Dexmedetomidine for Children Undergoing MRI Imaging

Phase 4
Conditions
MRI Sedation
Interventions
Drug: Dexmedetomidine
First Posted Date
2019-01-16
Last Posted Date
2019-01-25
Lead Sponsor
University of British Columbia
Target Recruit Count
180
Registration Number
NCT03806777

A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation

Phase 4
Completed
Conditions
Anxiety
Pharmacokinetics
Preoperative Care
Emergence Delirium
Interventions
Drug: Dexmedetomidine
First Posted Date
2019-01-11
Last Posted Date
2022-01-11
Lead Sponsor
Eye & ENT Hospital of Fudan University
Target Recruit Count
45
Registration Number
NCT03800641
Locations
🇨🇳

Eye, Ear, Nose and Throat Hospital, Shanghai, Shanghai, China

The Use of Dexmedetomidine for EEG Sedation in Children With Behavioural Disorders

Phase 2
Completed
Conditions
Procedural Sedation
Behavior Disorders
Interventions
Drug: dexmedetomidine
First Posted Date
2019-01-10
Last Posted Date
2021-02-02
Lead Sponsor
Azienda Ospedaliera di Padova
Target Recruit Count
19
Registration Number
NCT03799783
Locations
🇮🇹

Pediatric Intensive Care Unit - Department of Woman's and Child's Health - Azienda Ospedaliera di Padova, Padova, PD, Italy

Effects of Dexmedetomidine on Modulation of Perioperative Blood Glucose and Related Hormones

Not Applicable
Completed
Conditions
Dexmedetomidine
Blood Glucose
Interventions
Drug: dexmedetomidine
First Posted Date
2018-12-27
Last Posted Date
2021-02-03
Lead Sponsor
Zhuan Zhang
Target Recruit Count
75
Registration Number
NCT03788538
Locations
🇨🇳

the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China

KETODEX for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery

Completed
Conditions
Emergence Delirium
Strabismus
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-12-19
Last Posted Date
2018-12-19
Lead Sponsor
Ochsner Health System
Target Recruit Count
90
Registration Number
NCT03779282
Locations
🇺🇸

Ochsner Main Campus, Jefferson, Louisiana, United States

Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section

Phase 2
Completed
Conditions
Cesarean Section
Spinal Anesthesia
Dexmedetomidine
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-12-14
Last Posted Date
2019-01-15
Lead Sponsor
Menoufia University
Target Recruit Count
40
Registration Number
NCT03775655
Locations
🇪🇬

Menoufia University Hospitals, Shibīn Al Kawm, Menoufia, Egypt

Dexmedetomidine Versus Propofol in Conjunction With Regional Block for Shoulder Arthroscopy

Phase 4
Completed
Conditions
Hemodynamic
Sedation
Satisfaction, Personal
Interventions
Procedure: Shoulder Arthroscopy
Procedure: Regional Block
Drug: Dexmedetomidine
Drug: Propofol
Diagnostic Test: BIS
First Posted Date
2018-12-14
Last Posted Date
2018-12-17
Lead Sponsor
Saint-Joseph University
Target Recruit Count
60
Registration Number
NCT03775876
Locations
🇱🇧

Hotel Dieu de France Hospital, Beirut, Lebanon

Dexmedetomidine and Liver Transplantation

Early Phase 1
Completed
Conditions
Dexmedetomidine, Liver Transplantation, Allograft Function, Survival
Interventions
Drug: Saline
Drug: Dexmedetomidine
First Posted Date
2018-12-10
Last Posted Date
2023-08-21
Lead Sponsor
RenJi Hospital
Target Recruit Count
330
Registration Number
NCT03770130
Locations
🇨🇳

Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

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