Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine as Adjuvant for FNB in TKA

Not Applicable

Completed

Conditions: Nerve Block
Dexmedetomidine

Interventions: Drug: Dexmedetomidine
Device: intravenous patient-controlled analgesia pump with morphine
Procedure: ultrasound-guided femoral nerve block
Procedure: Continuous femoral nerve block

First Posted Date: 2018-09-05

Last Posted Date: 2018-11-16

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 90

Registration Number: NCT03658421

Locations: 🇨🇳
Department of Anesthesiology, First affiliated hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Phase 4

Conditions: Neurocognitive Disorders
Mental Disorders
Dexmedetomidine
Hypnotics and Sedatives
Delirium
Postoperative Complications
Physiological Effects of Drugs
Analgesics
Molecular Mechanisms of Pharmacological Action
Pathologic Processes

Interventions: Drug: Dexmedetomidine

First Posted Date: 2018-08-31

Last Posted Date: 2019-09-25

Lead Sponsor: Second Affiliated Hospital of Wenzhou Medical University

Target Recruit Count: 42

Registration Number: NCT03655847

Locations: 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)

Phase 3

Completed

Conditions: Critical Illness

Interventions: Drug: Propofol
Drug: Dexmedetomidine
Drug: Clonidine

First Posted Date: 2018-08-31

Last Posted Date: 2024-10-03

Lead Sponsor: University of Edinburgh

Target Recruit Count: 1437

Registration Number: NCT03653832

Locations: 🇬🇧
Belfast Health & Social Care Trust, Belfast, United Kingdom
🇬🇧
South Eastern Health and Social Trust, Belfast, United Kingdom
🇬🇧
University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

and more 35 locations

Efficacy and Safety of Dexmedetomidine During Weaning From Analgesia and Sedation in PICU (TIP-15-01)

Phase 2

Terminated

Conditions: Withdrawal Syndrome

Interventions: Drug: Dexmedetomidine
Drug: Placebo

First Posted Date: 2018-08-24

Last Posted Date: 2021-11-02

Lead Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

Target Recruit Count: 45

Registration Number: NCT03645603

Locations: 🇮🇹
PICU Policlinico S.Orsola-Malpighi, Bologna, Italy

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

Phase 4

Completed

Conditions: Anterior Cervical Discectomy and Fusion (ACDF)

Interventions: Drug: Remifentanil
Drug: Ketamine
Drug: Dexmedetomidine

First Posted Date: 2018-08-23

Last Posted Date: 2023-09-18

Lead Sponsor: University of Arkansas

Target Recruit Count: 32

Registration Number: NCT03643796

Locations: 🇺🇸
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain

Phase 4

Recruiting

Conditions: ACL Injury

Interventions: Drug: Dexamethasone 4mg
Drug: Dexmedetomidine
Other: Saline

First Posted Date: 2018-08-23

Last Posted Date: 2024-08-27

Lead Sponsor: Women's College Hospital

Target Recruit Count: 252

Registration Number: NCT03643822

Locations: 🇨🇦
Women's College Hospital, Toronto, Ontario, Canada

Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery

Phase 4

Completed

Conditions: Endothelial Dysfunction
Postoperative Cognitive Dysfunction
Blood Brain Barrier Defect

Interventions: Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2018-08-21

Last Posted Date: 2021-02-10

Lead Sponsor: The First Affiliated Hospital of Anhui Medical University

Target Recruit Count: 464

Registration Number: NCT03639896

Locations: 🇨🇳
The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
🇨🇳
Hangzhou cancer hospital, Hangzhou, Zhejiang, China