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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Procedure Sedation With Dexmedetomidine in Children With Autism Spectrum Disorders During Magnetic Resonance Imaging

Completed
Conditions
Autism Spectrum Disorder
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-07-24
Last Posted Date
2021-02-25
Lead Sponsor
Guangzhou Women and Children's Medical Center
Target Recruit Count
136
Registration Number
NCT03597477
Locations
🇨🇳

Guangzhou Women and Children Medical Center, Guangzhou, Guangdong, China

Effect of Dexmedetomidine on Emergence Agitation and Postoperative Behavior Changes in Children

Early Phase 1
Conditions
Emergence Agitation
Interventions
Drug: Dexmedetomidine
Drug: saline
First Posted Date
2018-07-24
Last Posted Date
2018-09-07
Lead Sponsor
Xuzhou Medical University
Target Recruit Count
96
Registration Number
NCT03596775
Locations
🇨🇳

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

Recruiting
Conditions
Drug Effect
Interventions
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Midazolam
Drug: Morphine
First Posted Date
2018-07-20
Last Posted Date
2024-11-14
Lead Sponsor
Boston Children's Hospital
Target Recruit Count
20
Registration Number
NCT03593408
Locations
🇺🇸

Boston Children's Hospital, Boston, Massachusetts, United States

Evaluating the Effects of Propofol vs. Dexmedetomidine

Conditions
Sedative Adverse Reaction
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2018-06-11
Last Posted Date
2019-07-24
Lead Sponsor
Children's Healthcare of Atlanta
Target Recruit Count
60
Registration Number
NCT03552146
Locations
🇺🇸

Children's Healthcare of Atlanta, Atlanta, Georgia, United States

Oral Dexmedetomidine for Parental Separation in Pediatrics Undergoing Adenotonsillectomy

Phase 4
Completed
Conditions
Adenotonsillectomy
Interventions
Combination Product: Midazolam/Ketamine
Drug: Dexmedetomidine
First Posted Date
2018-06-11
Last Posted Date
2018-07-05
Lead Sponsor
Suez Canal University
Target Recruit Count
74
Registration Number
NCT03551067
Locations
🇪🇬

Anesthesia Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Wound Infiltration as Part of an Opioid Free Pain Management Pathway Following Cesarean Delivery

Phase 2
Conditions
Pain, Postoperative
Opioid Use
Anesthesia, Local
Interventions
Drug: Placebo
Drug: Bupivacaine
Drug: Dexmedetomidine
First Posted Date
2018-06-04
Last Posted Date
2018-08-29
Lead Sponsor
Richmond University Medical Center
Target Recruit Count
540
Registration Number
NCT03545516
Locations
🇺🇸

Richmond University Medical Center, Staten Island, New York, United States

Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP

Not Applicable
Completed
Conditions
Prostate Cancer
Interventions
Drug: Dexmedetomidine
Other: Without dexmedetomidine
First Posted Date
2018-05-18
Last Posted Date
2018-09-13
Lead Sponsor
Asan Medical Center
Target Recruit Count
128
Registration Number
NCT03529643
Locations
🇰🇷

Asan medical Center, Seoul, Korea, Republic of

Effect of Dexmedetomidine on Stress Study of Pituitrin in Laparoscopic Hysteromyoma Surgery

Phase 3
Conditions
Hysteromyoma
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-05-15
Last Posted Date
2018-05-15
Lead Sponsor
Beijing Anzhen Hospital
Target Recruit Count
90
Registration Number
NCT03524950

Multimodal Analgesia Versus Traditional Opiate Based Analgesia

First Posted Date
2018-05-11
Last Posted Date
2018-05-11
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
225
Registration Number
NCT03521167

Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation

Phase 4
Active, not recruiting
Conditions
Acute Kidney Injury
Liver Diseases
Interventions
Drug: Normal saline
Drug: Dexmedetomidine
First Posted Date
2018-05-11
Last Posted Date
2023-07-17
Lead Sponsor
Asan Medical Center
Target Recruit Count
214
Registration Number
NCT03522688
Locations
🇰🇷

Asan medical center, Seoul, Songpa-gu, Korea, Republic of

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