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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery

Phase 4
Conditions
Elderly
Orthopedic Surgery
Analgesia
Dexmedetomidine
Postoperative Delirium
Long-term Outcome
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2018-08-14
Last Posted Date
2021-07-07
Lead Sponsor
Peking University First Hospital
Target Recruit Count
712
Registration Number
NCT03629262
Locations
🇨🇳

Peking University First Hospital, Beijing, China

🇨🇳

Beijing Jishuitan Hospital, Beijing, China

Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block

Phase 4
Suspended
Conditions
Elderly
Knee Arthroplasty
Nerve Block
Dexmedetomidine
Postoperative Delirium
Long-term Outcome
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2018-08-14
Last Posted Date
2022-04-26
Lead Sponsor
Peking University First Hospital
Target Recruit Count
736
Registration Number
NCT03629483
Locations
🇨🇳

Peking University First Hospital, Beijing, Beijing, China

🇨🇳

Beijing Jishuitan Hospital, Beijing, Beijing, China

Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery

Not Applicable
Active, not recruiting
Conditions
Cardiac Surgery
Cardiopulmonary Bypass
Dexmedetomidine
Survival
Delirium
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2018-08-10
Last Posted Date
2024-05-14
Lead Sponsor
Dong-Xin Wang
Target Recruit Count
502
Registration Number
NCT03624595
Locations
🇨🇳

Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, Beijing, China

🇨🇳

Beijing University First Hospital, Beijing, Beijing, China

The Effect of Dexmedetomidine for Emergence Cough

Not Applicable
Completed
Conditions
Cough
Interventions
Drug: Dexmedetomidine
Drug: Remifentanil
Drug: Normal saline
First Posted Date
2018-08-09
Last Posted Date
2020-01-09
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
48
Registration Number
NCT03622502
Locations
🇰🇷

Ajou University Hospital, Suwon, Gyeongki-do, Korea, Republic of

Dex as Analgesic Adjuvant in OSA Patients

Phase 1
Withdrawn
Conditions
Obstructive Sleep Apnea
Interventions
Drug: Dexmedetomidine
Drug: Placebo
First Posted Date
2018-08-03
Last Posted Date
2018-08-03
Lead Sponsor
Montefiore Medical Center
Registration Number
NCT03613558
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Effects of Dexmedetomidine on OI, RI and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty.

Not Applicable
Conditions
Adverse Effect
Interventions
Other: normal saline
Drug: dexmedetomidine
First Posted Date
2018-08-02
Last Posted Date
2018-08-02
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
80
Registration Number
NCT03612440
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Dexamethasone Versus Dexmedetomidine as Adjuvants for Nerve Blocks

Not Applicable
Completed
Conditions
Upper Extremity Injury
Pain, Acute
Pain, Postoperative
Interventions
Drug: Dexamethasone
Drug: Dexmedetomidine
First Posted Date
2018-08-01
Last Posted Date
2019-05-01
Lead Sponsor
University of Chile
Target Recruit Count
120
Registration Number
NCT03610893
Locations
🇨🇱

Hospital Clínico Universidad de Chile, Santiago, Metropolitana, Chile

Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy

Not Applicable
Conditions
Effect of Drugs
Interventions
Drug: Dexmedetomidine
Drug: Placebo
First Posted Date
2018-07-26
Last Posted Date
2018-08-03
Lead Sponsor
Suez Canal University
Target Recruit Count
52
Registration Number
NCT03600506

Propofol and Dexmedetomidine on Inflammation

Not Applicable
Conditions
Inflammation
Postoperative Delirium
Anesthesia
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2018-07-26
Last Posted Date
2018-07-26
Lead Sponsor
The First Affiliated Hospital of Anhui Medical University
Target Recruit Count
200
Registration Number
NCT03600727

Adjuvant to General Anesthesia in Patients Undergoing Major Abdominal Surgeries

Phase 4
Conditions
Stress Related Disorder
Interventions
Drug: Lidocaine
Drug: Dexmedetomidine
First Posted Date
2018-07-26
Last Posted Date
2018-08-03
Lead Sponsor
Suez Canal University
Target Recruit Count
64
Registration Number
NCT03600493
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